490-18-6

Basic information

• Product Name: (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99
• Synonyms: (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99;(1A,2A,3B,4B)-2,4-bis(4-hydroxyphenyl)-1,3-cyclob;(1alpha,2alpha,3beta,4beta)-2,4-Bis(4-hydroxyphenyl)-1,3-cyclobutanedicarboxylic acid;(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99%;(1α,2α,3β,4β)-2,4-Bis(4-hydroxyphenyl)-1,3-cyclobutanedicarboxylic acid
• CAS NO: 490-18-6
• Molecular Formula: C₁₈H₁₆O₆
• Molecular Weight: 328.31604
• Mol File: 490-18-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 200-250 °C
• Appearance: /
• Density: 1.487±0.06 g/cm3(Predicted)
• PKA: 3.94±0.70(Predicted)
• CAS DataBase Reference: (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99(CAS DataBase Reference)
• NIST Chemistry Reference: (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99(490-18-6)
• EPA Substance Registry System: (1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99(490-18-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 490-18-6(Hazardous Substances Data)

Usage

Description

(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 is a cyclobutane-based compound featuring two hydroxylphenyl groups attached to it. This white to off-white powder boasts a purity of 99% and is characterized by its unique chemical properties, making it a valuable asset in research and development laboratories. Its composition and structure contribute to its potential applications across various industries, including pharmaceuticals, polymer synthesis, and as a chemical intermediate.

Uses

Used in Pharmaceutical Industry:
(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 serves as a key component in the development of pharmaceuticals, leveraging its unique structure to enhance drug efficacy and target specific biological pathways.
Used in Polymer Synthesis:
In the field of polymer chemistry, this compound acts as a crucial building block, contributing to the creation of novel polymers with tailored properties for various applications.
Used as a Chemical Intermediate:
(1A,2A,3B,4B)-2,4-BIS(4-HYDROXYPHENYL)-1,3-CYCLOBUTANEDICARBOXYLIC ACID, 99 is utilized as an intermediate in the synthesis of other complex organic compounds, facilitating the production of a wide range of chemical products.

Upstream product

• 7400-08-0 p-Coumaric Acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1428579-86-5 (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid 

Downstream Products

• 36650-53-0 dimethyl 4,4'-dimethoxy-α-truxillate 
• 133098-91-6 C₃₀H₄₈O₆Si₄ 
• 40493-54-7 4,4'-Dimethoxy-α-truxillsaeure 
• 40493-49-0 p,p'-Dimethoxy-α-truxillsaeure-dichlorid 
• 75456-19-8 [3-Carboxymethyl-2,4-bis-(4-methoxy-phenyl)-cyclobutyl]-acetic acid 
• 75456-18-7 1α,3β-bis(carbomethoxymethyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane 
• 75456-17-6 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane 

Relevant articles and documents

Anti-inflammatory activities of α-truxillic acid derivatives and their monomer components

The anti-inflammatory activities of α-truxillic acid (1) and 4,4′-dihydroxy-α-truxillic acid (2) as well as their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) were evaluated in the formalin test. α-Truxillic acid (1) and its deriva

Remarkably high homoselectivity in [2 + 2] photodimerization of: Trans -cinnamic acids in multicomponent systems

[2 + 2] homoadducts were exclusively obtained with total regio- and stereo-selectivities when a suspension of several solid photoactive trans-cinnamic acids in cyclohexane was stirred and irradiated.

Templating photodimerization of trans-cinnamic acids with cucurbit[8]uril and γ-cyclodextrin

(Chemical Equation Presented) Cucurbit[8]uril and γ-cyclodextrin are able to align two olefin molecules in a head-head fashion within their large cavities. Excitation of such templated olefins results in syn head-head cyclobutanes in nearly quantitative yields. The methodology revealed here works with trans-cinnamic acids that do not dimerize either in solution or in the solid state and with the ones that yield only anti head-tail dimer in the solid state.