490-80-2

Basic information

• Product Name: 2,5-dihydroxybenzoate
• Synonyms: 2,5-dihydroxybenzoate
• CAS NO: 490-80-2
• Molecular Formula: C₇H₅O₄
• Molecular Weight: 0
• Mol File: 490-80-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 406.9°Cat760mmHg
• Flash Point: 214°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 2,5-dihydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dihydroxybenzoate(490-80-2)
• EPA Substance Registry System: 2,5-dihydroxybenzoate(490-80-2)

Safety Data

• Hazardous Substances Data: 490-80-2(Hazardous Substances Data)

Usage

Description

2,5-Dihydroxybenzoate is a dihydroxybenzoate that is the conjugate base of 2,5-dihydroxybenzoic acid, and it is the major species at pH 7.3. It is an organic compound with two hydroxyl groups attached to the 2nd and 5th positions of a benzene ring, which gives it unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
2,5-Dihydroxybenzoate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form conjugate bases at physiological pH makes it a versatile building block for the development of new drugs with potential applications in treating various diseases.
Used in Chemical Industry:
In the chemical industry, 2,5-dihydroxybenzoate is used as a starting material for the production of various organic compounds, such as dyes, pigments, and polymers. Its unique chemical structure allows for the creation of a wide range of products with different properties and applications.
Used in Cosmetics Industry:
2,5-Dihydroxybenzoate is used as a preservative and antioxidant in the cosmetics industry. Its ability to form stable conjugate bases at pH 7.3 makes it an effective agent for preventing the growth of microorganisms and oxidation in cosmetic products, thus extending their shelf life and maintaining their quality.
Used in Food Industry:
In the food industry, 2,5-dihydroxybenzoate is used as an additive for its preservative and antioxidant properties. It helps to extend the shelf life of food products by inhibiting the growth of bacteria and other microorganisms, as well as preventing the oxidation of fats and oils, which can lead to rancidity and spoilage.
Used in Environmental Applications:
2,5-Dihydroxybenzoate can be used in environmental applications, such as the treatment of wastewater and the removal of pollutants from the environment. Its ability to form complexes with various metal ions and other contaminants makes it a potential candidate for use in water purification and pollution control processes.

Upstream product

• 10476-50-3 3-hydroxybenzoate 
• 490-79-9 2,5-dihydroxybenzoic acid. 

Relevant articles and documents

Advanced oxidation processes for the removal of [bmim][Sal] third generation ionic liquids: Effect of water matrices and intermediates identification

Unique properties of ionic liquids make them green alternatives for conventional volatile organic compounds. Due to increased production and the high stability of these substances, they could be classified as persistent pollutants and could break through classical treatment systems into natural waters. A preliminary ionic liquid hydrolysis study demonstrated a pH dependent degradation profile with a significant decrease in hydrolysis efficiency as pH lowered from 10.0 to 2.8. In order to examine future prospects for ionic liquid removal, different advanced oxidation processes (TiO2 Degussa P25/H2O2, TiO2 Degussa P25, 7.2Fe/TiO2/H2O2, and H2O2) were studied for their applicability in the degradation of imidazolium-based ionic liquids in aqueous solution. These processes were conducted in the dark as well as in the presence of UVA and simulated sunlight (SS) radiation. Among the investigated dark processes, the 7.2Fe/TiO2/H2O2 system showed the highest efficiency, which can be attributed to a dark heterogeneous Fenton process. Otherwise, the most efficient among all the studied degradation processes was the UVA/TiO2 Degussa P25/H2O2 process. In order to make degradation processes more similar to that of the practical process SS radiation was used. Among studied processes, the 7.2Fe/TiO2/H2O2 system showed the greatest potential for the removal of ionic liquids. Also, it was observed that the impact of anions on the cation degradation efficiency was much more pronounced. Due to the possible fate of ionic liquids in the environment, for five different waters (pond, rain, tap, river, and condensate) degradations in the dark and under simulated sunlight were studied. For all processes, and all water types in the presence of SS radiation a remarkable positive effect of naturally dissolved organic matter on the degradation efficiency was observed. Also, in all experiments, the anion was less stable than the cation. The major photodegradation products identified using liquid chromatography-mass spectrometry (HPLC-MS/MS) techniques were hydroxylated compounds.

Flavoenzyme-mediated Regioselective Aromatic Hydroxylation with Coenzyme Biomimetics

Regioselective aromatic hydroxylation is desirable for the production of valuable compounds. External flavin-containing monooxygenases activate and selectively incorporate an oxygen atom in phenolic compounds through flavin reduction by the nicotinamide adenine dinucleotide coenzyme, and subsequent reaction with molecular oxygen. This study provides the proof of principle of flavoenzyme-catalyzed selective aromatic hydroxylation with coenzyme biomimetics. The carbamoylmethyl-substituted biomimetic in particular affords full conversion in less than two hours for the selective hydroxylation of 5 mM 3- and 4-hydroxybenzoates, displaying similar rates as with NADH, achieving a 10 mM/h enzymatic conversion of the medicinal product gentisate. This biomimetic appears to generate less uncoupling of hydroxylation that typically leads to undesired hydrogen peroxide. Therefore, we show these flavoenzymes have the potential to be applied in combination with biomimetics.