490039-75-3 Usage
Derivative of indole
A heterocyclic aromatic compound
Contains a carbonitrile functional group
A cyano group (CN) attached to the indole ring
Contains a sulfonyl group
A group containing a sulfur atom bonded to two oxygen atoms (-SO2)
Attached to the indole ring
The carbonitrile and sulfonyl groups are both directly bonded to the indole ring
Presence of the iodo and phenylsulfonyl groups
The molecule contains an iodine atom and a phenylsulfonyl group (C6H5SO2)
Useful in organic synthesis
The presence of the iodo and phenylsulfonyl groups makes the compound a valuable intermediate in organic synthesis
Building block in the pharmaceutical industry
The compound is used as a starting material for the development of new drugs and pharmaceutical agents
Important applications in research and industrial settings
The compound has a wide range of potential uses in both academic and commercial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 490039-75-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,0,0,3 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 490039-75:
(8*4)+(7*9)+(6*0)+(5*0)+(4*3)+(3*9)+(2*7)+(1*5)=153
153 % 10 = 3
So 490039-75-3 is a valid CAS Registry Number.
490039-75-3Relevant articles and documents
Carbopalladation of nitriles: Synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles
Pletnev, Alexandre A.,Tian, Qingping,Larock, Richard C.
, p. 9276 - 9287 (2007/10/03)
2-Iodobenzonitrile, its derivatives, and various heterocyclic analogues undergo palladium(O)-catalyzed annulation onto diarylacetylenes or bicyclic alkenes to afford 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields. This reaction represents one of the first examples of the addition of an organopalladium moiety to the carbon-nitrogen triple bond of a nitrile. The reaction is compatible with a number of functional groups. A reaction mechanism, as well as a model accounting for the electronic effects of substituents on the aromatic ring of the nitrile, is proposed.
