491024-68-1

Basic information

• Product Name: 2,6-Pyridinedicarboxamide, 4-chloro-N,N'-bis[2-[(4S)-4,5-dihydro-4-methyl-2-oxazolyl]phenyl]-
• CAS NO: 491024-68-1
• Molecular Formula: C27H24ClN5O4
• Molecular Weight: 517.972
• Mol File: 491024-68-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-Pyridinedicarboxamide, 4-chloro-N,N'-bis[2-[(4S)-4,5-dihydro-4-methyl-2-oxazolyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Pyridinedicarboxamide, 4-chloro-N,N'-bis[2-[(4S)-4,5-dihydro-4-methyl-2-oxazolyl]phenyl]-(491024-68-1)
• EPA Substance Registry System: 2,6-Pyridinedicarboxamide, 4-chloro-N,N'-bis[2-[(4S)-4,5-dihydro-4-methyl-2-oxazolyl]phenyl]-(491024-68-1)

Safety Data

• Hazardous Substances Data: 491024-68-1(Hazardous Substances Data)

Upstream product

• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 209850-74-8 2-[(4S)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]aniline 
• 491024-78-3 N-(2-hydroxy-(1S)-1-methylethyl)-2-nitrobenzamide 
• 491024-82-9 N-(2-chloro-(1S)-1-methylethyl)-2-nitrobenzamide 
• 491024-87-4 (4S)-4-methyl-2-(2-nitrophenyl)-4,5-dihydro-1,3-oxazole 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 

Relevant articles and documents

Dynamic helical chirality of an intramolecularly hydrogen-bonded bisoxazoline

The synthesis and conformational properties of 2,6-bis-[2-((4S)-4-methyl-4,5-dihydro-1,3-oxazol-2- yl)phenyl]carbam oylpyridines, 2, have been described. Bisoxazoline 2a was prepared in five steps from 2-nitrobenzoyl chloride in an overall yield of 71%. In contrast to related structures such as 1, bisoxazoline 2a exhibits a highly biased P-type helical conformation in solution and in the solid state. In the crystal lattice, 2a further assembles into a left-handed helical superstructure aligned along the crystallographic c axis. The barrier to helical interconversion, as measured by line-shape analysis of the temperature-dependent 1H NMR spectra of thiobenzyl derivative 2b, was determined to be quite low (ΔG? = 12.3 kcal/mol), indicating the presence of a highly dynamic helical chirality.