4915-97-3

Basic information

• Product Name: 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• Synonyms: 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• CAS NO: 4915-97-3
• Molecular Weight: 217.227
• Mol File: 4915-97-3.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester(4915-97-3)
• EPA Substance Registry System: 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester(4915-97-3)

Safety Data

• Hazardous Substances Data: 4915-97-3(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 623-47-2 propynoic acid ethyl ester 
• 622-37-7 Phenyl azide 
• 140-88-5 ethyl acrylate 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 5941-50-4 (E)-ethyl 3-nitroacrylate 
• 5941-50-4 ethyl β-nitroacrylate 
• 14762-48-2 ethyl 2-diazo-3-oxo-propanoate 

Downstream Products

• 103755-58-4 (1-phenyl-1H-1,2,3-triazole-4-yl)methanol 
• 214541-36-3 1-Phenyl-1H-[1,2,3]triazole-4-carboxylic acid dimethylamide 
• 134541-91-6 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid chloride 
• 4600-04-8 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid 

Relevant articles and documents

Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease

Alzheimer disease is multi-factorial and inflammation plays a major role in the disease progression and severity. Metals and reactive oxygen species (ROS) are the key mediators for inflammatory conditions associated with Alzheimer's. Along multi-factorial nature, major challenge for developing new drug is the ability of the molecule to cross blood brain barrier (BBB). We have designed and synthesized multi-target directed hexafluorocarbinol containing triazoles to inhibit Amyloid β aggregation and simultaneously chelate the excess metals present in the extracellular space and scavenge the ROS thus reduce the inflammatory condition. From the screened compound library, compound 1c found to be potent and safe. It has demonstrated inhibition of Amyloid β aggregation (IC50 of 4.6 μM) through selective binding with Amyloid β at the nucleation site (evidenced from the molecular docking). It also chelate metals (Cu+2, Zn+2 and Fe+3) and scavenges ROS significantly. Due to the presence of hexafluorocarbinol moiety in the molecule it may assist to permeate BBB and improve the pharmacokinetic properties. The in-vitro results of compound 1c indicate the promiscuity for the development of hexafluorocarbinol containing triazoles amide scaffold as multi-target directed therapy against Alzheimer disease.

Water as a solvent for Ru-catalyzed click reaction: Highly efficient recyclable catalytic system for triazolocoumarins synthesis

A new family of Ru (III) complexes has been synthesized, characterized and their catalytic performance has been tested for alkyne–azide cycloaddition (AAC) in water under ultrasonic irradiation conditions. These complexes are found to be effective heterog

NOVEL OXABOROLE ANALOGS AND USES THEREOF

This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite.