491578-01-9Relevant articles and documents
Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines
Jeong, Lak Shin,Zhao, Long Xuan,Choi, Won Jun,Pal, Shantanu,Park, Yeon Hee,Lee, Sang Kook,Chun, Moon Woo,Lee, Young B.,Ahn, Chang Ho,Moon, Hyung Ryong
, p. 713 - 716 (2007)
Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer
Regio- and stereoselective synthesis of 2′-β-substituted-fluoroneplanocin A analogues as potential anticancer agents
Nayak, Akshata,Sahu, Pramod K.,Song, Jayoung,Lee, Sang Kook,Jeong, Lak Shin
, p. 9236 - 9248 (2015/09/07)
A series of 2′-β-substituted-6′-fluoro-cyclopentenyl-pyrimidines and -purines 8 and 9 were successfully synthesized from D-ribose in a regio- and stereoselective manner. The functionalization at the C2-position of 6′-fluoro-cyclopentenyl nucleosides was a
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues
Lee, Kang Man,Choi, Won Jun,Lee, Yoonji,Lee, Hyun Joo,Zhao, Long Xuan,Lee, Hyuk Woo,Park, Jae Gyu,Kim, Hea Ok,Hwang, Kwang Yeon,Heo, Yong-Seok,Choi, Sun,Jeong, Lak Shin
, p. 930 - 938 (2011/04/24)
The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation