4916-29-4

Basic information

• Product Name: dimethyl 2-(phenylamino)maleate
• Synonyms: dimethyl 2-(phenylamino)maleate
• CAS NO: 4916-29-4
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 415.46284
• Mol File: 4916-29-4.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dimethyl 2-(phenylamino)maleate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(phenylamino)maleate(4916-29-4)
• EPA Substance Registry System: dimethyl 2-(phenylamino)maleate(4916-29-4)

Safety Data

• Hazardous Substances Data: 4916-29-4(Hazardous Substances Data)

Upstream product

• 553-90-2 Dimethyl oxalate 
• 124-41-4 sodium methylate 
• 62-53-3 aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 25007-54-9 Dimethyl 2-oxosuccinate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 24371-06-0 1-Anilino-1,2,3,4-tetramethoxycarbonyl-buten-(1,3) 
• 100391-40-0 N-phenylaspartic acid methyl ester 
• 22273-65-0 4-(phenylamino)furan-2(5H)-one 
• 92952-50-6 tetramethyl 5-anilino-1-phenyl-2-pyrroline-2,3,4,5-tetracarboxylate 
• 7101-89-5 4-oxo-1,4-dihydroquinoline-2-carboxylic acid methyl ester 
• 251986-52-4 4,5-dimethoxycarbonyl-1-phenyl-1H-pyrrole-2,3-dione 
• 61707-79-7 1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 13593-94-7 kynurenic acid 
• 37802-39-4 tetramethyl 1-phenylpyrrole-2,3,4,5-tetracarboxylate 
• 2226-83-7 N-phenyl-DL-aspartic acid ; inactive anilinosuccinic acid 
• 36920-53-3 4-oxo-1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 3421-08-7 2,5-bis(phenylamino)-1,4-benzoquinone 
• 17507-03-8 dimethyl quinoline-2,3-dicarboxylate 

Relevant articles and documents

Synthesis, crystal structure and dft studies of polyfunctionalized alkenes: A transition metal-free c(sp2)-h sulfenylation of electron deficient alkyne

An efficient, novel and transition metal-free protocol has been developed for the synthesis of polyfunctionalized aminothioalkenes via direct C[sbnd]H sulfenylation of in situ generated enamines. The reaction was performed using a catalytic amount of inex

Copper-Catalyzed Three-Component Cascade Michael Addition/Heck-Type Alkylation/Annulation: Accessing Fully Substituted 1,3-Dihydro-2 H-pyrrol-2-ones

We report a highly efficient copper-catalyzed three-component reaction of alkylamines, acetylenedicarboxylates, and α-bromocarbonyls for the assembly of fully substituted 1,3-dihydro-2H-pyrrol-2-ones. A variety of alkylamines and ammonium salt are functionalized with acetylenedicarboxylates and α-bromocarbonyls. N-aryl enaminoesters are also successfully alkylated with α-bromocarbonyls. This protocol is understood to proceed through radical Heck-type coupling of in-situ-generated bulky trisubstituted alkenes with bulky tertiary alkyl bromides, which is realized for the first time.

Base-Catalyzed Tandem Cyclization: Diastereoselective Access to the 3,4-Dihydroisoquinolin-2(1 H)-one Core

A novel, one-pot reaction for the synthesis of 3,4-dihydroisoquinolin-2(1 H)-one derivatives is developed via a base-mediated three-component reaction of ninhydrin, aniline and acetylenic esters. This diastereoselective reaction takes place in methanol at 70A °C under transition-metal-free conditions, and direct construction of the C-N and C-C bonds is readily achieved via tandem cyclization. These cyclic frameworks are resourceful small molecular keys to many natural products.