492-02-4

Basic information

• Product Name: 1,2-Bis(N-cytisinyl)ethane
• CAS NO: 492-02-4
• Molecular Weight: 406.528
• Mol File: 492-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Bis(N-cytisinyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(N-cytisinyl)ethane(492-02-4)
• EPA Substance Registry System: 1,2-Bis(N-cytisinyl)ethane(492-02-4)

Safety Data

• Hazardous Substances Data: 492-02-4(Hazardous Substances Data)

Usage

Uses

CC4 is a cytisine dimer and a selective partial nAChR (α4β2 /α6β2 ) agonist.

Upstream product

• 107-04-0 1-Bromo-2-chloroethane 
• 485-35-8 cytisine 
• 107-06-2 1,2-dichloro-ethane 

Relevant articles and documents

Synthesis and preliminary pharmacological evaluation of some cytisine derivatives

Thirty-one N-derivatives of cytisine were prepared in order to modify its pharmacological profile and to obtain compounds of potential therapeutic interest either at a peripheral or central level, particularly as nicotinic ligands with improved ability to cross the blood-brain barrier. Actually, with the introduction of different kinds of substituent on the basic nitrogen of cytisine a variety of activities were observed, both in vivo (analgesic, dopamine antagonism, antihypertensive, inhibition of stress-induced ulcers, antiinflammatory, protection from PAF-induced mortality, hypoglycemic) and in vitro (positive cardio-inotropic, β-adrenergic antagonism, α1- and α2-antagonism, inhibition of PAF-induced platelet aggregation). Six randomly selected compounds were tested for the ability to recognize a central nicotinic receptor and four of them exhibited K(i) values in the range 30-163 nM.