492-16-0

Basic information

• Product Name: 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE
• Synonyms: 2-PHENYL-(2,2,2-TRIFLUOROACETYL)ACETONITRILE;2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE;BUTTPARK 82\12-90;2-Phenyl-2-(2,2,2-trifluoroacetyl)-acetonitrile;2-PHENYL-(2,2,2-TRIFLUOROACETYL)ACETONITRILE, 97% MIN.;alpha-(Trifluoroacetyl)benzeneacetonitrile, 3-Oxo-2-pheny-4,4,4-trifluorolbutanenitrile;4,4,4-Trifluoro-3-oxo-2-phenyl-butyronitrile;Benzeneacetonitrile, a-(trifluoroacetyl)-
• CAS NO: 492-16-0
• Molecular Formula: C₁₀H₆F₃NO
• Molecular Weight: 213.16
• Mol File: 492-16-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 82-84°C
• Boiling Point: 219.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.308±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE(492-16-0)
• EPA Substance Registry System: 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE(492-16-0)

Safety Data

• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 22-26-36/37/39
• RIDADR: 3439
• Hazardous Substances Data: 492-16-0(Hazardous Substances Data)

Usage

General Description

2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE is a chemical compound with the molecular formula C11H7F3N and a molecular weight of 217.17 g/mol. It is a white to pale yellow solid that is soluble in organic solvents such as ethanol and ethyl ether. 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of dyes and perfumes. Additionally, 2-PHENYL-2-(TRIFLUOROACETYL)ACETONITRILE is known to be a versatile building block in organic chemistry, enabling the creation of a wide variety of complex molecules. Its trifluoroacetyl group makes it a valuable reagent for introducing this functional group into organic compounds.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 140-29-4 phenylacetonitrile 
• 108-86-1 bromobenzene 

Downstream Products

• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 434-80-0 4,4,4-trifluoro-2-phenyl-acetoacetic acid amide 
• 428-84-2 5-benzyl-5-trifluoromethyl-imidazolidine-2,4-dione 
• 404-20-6 (+/-)-1,1,1-trifluoro-3-phenyl-2-aminopropane 
• 322-01-0 rac-3,3,3-trifluoro-2-hydroxy-1-phenylpropan-1-one 
• 395-15-3 3-Bromo-3-phenyl-1,1,1-trifluoro-propan-2-one 
• 578-88-1 1,1,1-trifluoro-3-methoxy-3-phenyl-2-propanone 
• 389-59-3 1,2-diacetoxy-3,3,3-trifluoro-1-phenyl-propene 
• 345-80-2 3,3,3-trifluoro-1-phenyl-prop-1-ene-1,2-diol 
• 62649-36-9 4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine 
• 1404447-43-3 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 75-89-8 2,2,2-trifluoroethanol 
• 103-81-1 Benzeneacetamide 

Relevant articles and documents

Synthesis and cytotoxic evaluation of some new 1-(6- chloropyridazin-3-Yl)-3-H/Alkyl-4-phenyl-1H-pyrazol- 5-amines and their derivatives

Synthesis of new 1-(6-chloropyridazin-3-yl)-3-H/alkyl-4-phenyl-1H-pyrazol-5-amines (3) was accomplished by the reaction of 3-chloro-6-hydrazinopyridazine (1) with differently substituted β-ketonitriles (2) under reflux in ethanol. Subsequently, a series of 6-amino derivatives (4, 5 and 6) was synthesized by amino-de-halogenation of 3 with secondry cyclic amines e.g. pyrrolidine, piperidine and morpholine respectively. Structures of all the compounds were established by IR, NMR (1H, 13C and 19F) and mass spectral data, and elemental analysis. All the compounds were screened for their cytotoxic effects against three cancer cell lines (SB-ALL, NALM-6, MCF-7) using colorimetric MTT assay.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.