492448-53-0

Basic information

• Product Name: Silane, [(2-ethylphenyl)ethynyl]trimethyl- (9CI)
• Synonyms: Silane, [(2-ethylphenyl)ethynyl]trimethyl- (9CI)
• CAS NO: 492448-53-0
• Molecular Formula: C₁₃H₁₈Si
• Molecular Weight: 202.36752
• Product Categories: ETHYL
• Mol File: 492448-53-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 248.4±23.0 °C(Predicted)
• Appearance: /
• Density: 0.90±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Silane, [(2-ethylphenyl)ethynyl]trimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [(2-ethylphenyl)ethynyl]trimethyl- (9CI)(492448-53-0)
• EPA Substance Registry System: Silane, [(2-ethylphenyl)ethynyl]trimethyl- (9CI)(492448-53-0)

Safety Data

• Hazardous Substances Data: 492448-53-0(Hazardous Substances Data)

Upstream product

• 18282-40-1 1-ethyl-2-iodobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 1973-22-4 1-bromo-2-ethylbenzene 

Downstream Products

• 75659-49-3 1-ethyl-2-ethynylbenzene 
• 1378975-93-9 4-(2-ethylphenyl)-1H-1,2,3-triazole 

Relevant articles and documents

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.

Palladium-catalyzed carbon-carbon coupling reactions using aryl Grignards

Coupling reactions using Pd(PPh3)4 were investigated with a number of electron donating and electron withdrawing substituents. High yields were obtained with both types of substituents. In competitive reactions the electron-withdrawi