4928-43-2

Basic information

• Product Name: N2,N2-dimethylpyridine-2,5-diamine
• Synonyms: N,N-Dimethylpyridine-2,5-diamine;N,N-Dimethyl-2,5-pyridinediamine;(5-amino-2-pyridyl)-dimethyl-amine;N~2~,N~2~-dimethyl-2,5-pyridinediamine(SALTDATA: FREE);2-Dimethylamino-5-aminopyridine;3-Amino-6-(dimethylamino)pyridine;5-Amino-2-(dimethylamino)pyridine
• CAS NO: 4928-43-2
• Molecular Formula: C₇H₁₁N₃
• Molecular Weight: 137.19
• EINECS: 225-564-7
• Product Categories: pharmacetical
• Mol File: 4928-43-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 283.4°C at 760 mmHg
• Flash Point: 125.2°C
• Appearance: /
• Density: 1.115g/cm³
• Vapor Pressure: 0.00317mmHg at 25°C
• Refractive Index: 1.614
• PKA: 7.87±0.10(Predicted)
• CAS DataBase Reference: N2,N2-dimethylpyridine-2,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N2,N2-dimethylpyridine-2,5-diamine(4928-43-2)
• EPA Substance Registry System: N2,N2-dimethylpyridine-2,5-diamine(4928-43-2)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 4928-43-2(Hazardous Substances Data)

Usage

General Description

N2, N2-dimethylpyridine-2,5-diamine is a chemical compound that belongs to the class of compounds known as meta-aminophenols. These are organic polycyclic compounds that contain a benzene ring with two adjacent carbon atoms each bearing an amino group (-NH2). It also features two linked methyl groups (-CH3). The chemical formula for N2, N2-dimethylpyridine-2,5-diamine is C7H11N3, and it is often used in the synthesis of various organic compounds in the field of pharmaceuticals and biochemistry. The chemical possesses a strong nucleophilic property, meaning that it has the capacity to donate electron pairs to other compounds, a feature that makes it useful in chemical reactions.

InChI:InChI=1/C7H11N3/c1-10(2)7-4-3-6(8)5-9-7/h3-5H,8H2,1-2H3

Upstream product

• 2554-75-8 N,N-dimethyl-5-nitropyridin-2-amine 
• 7647-01-0 hydrogenchloride 
• 5683-33-0 2-(Dimethylamino)pyridine 
• 124-40-3 dimethyl amine 
• 1083329-54-7 5-N-benzylamino-2-N,N-dimethylaminopyridine 
• 26163-07-5 5-bromo-2-dimethylaminopyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 4487-59-6 2-bromo-5-nitropyridine 

Downstream Products

• 1003938-52-0 N-[6-(dimethylamino)pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide 
• 1379032-15-1 5-(3-bromo-4-hydroxybenzylidene)-3-[6-(dimethylamino)pyridine-3-yl]-1,3-oxazolidin-2,4-dione 
• 1435933-28-0 C₁₉H₂₅N₃O₂ 

Relevant articles and documents

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

Discovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives

We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound 7 (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (15d; human TRPV1 IC50 = 33 nM). In addition, 15d ameliorated bladder overactivity in rats in vivo.

Preparation of highly reactive pyridine- and pyrimidine-containing diarylamine antioxidants

We recently reported a preliminary account of our efforts to develop novel diarylamine radical-trapping antioxidants (Hanthorn, J. J. et al. J. Am. Chem. Soc. 2012, 134, 8306-8309) wherein we demonstrated that the incorporation of ring nitrogens into diphenylamines affords compounds which display a compromise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation. Herein we provide the details of the synthetic efforts associated with that report, which have been substantially expanded to produce a library of substituted heterocyclic diarylamines that we have used to provide further insight into the structure-reactivity relationships of these compounds as antioxidants (see the accompanying paper, DOI: 10.1021/jo301012x). The diarylamines were prepared in short, modular sequences from 2-aminopyridine and 2-aminopyrimidine wherein aminations of intermediate pyri(mi)dyl bromides and then Pd-catalyzed cross-coupling reactions of the amines and precursor bromides were the key steps to yield the diarylamines. The cross-coupling reactions were found to proceed best with Pd(η3-1-PhC3H 4)(η5-C5H5) as precatalyst, which gave higher yields than the conventional Pd source, Pd2(dba) 3.