493005-73-5

Basic information

• Product Name: L-Methionine, N-[4-[[4-(4-nitrophenyl)-1-oxobutyl]amino]benzoyl]-, methyl ester
• CAS NO: 493005-73-5
• Molecular Formula: C23H27N3O6S
• Molecular Weight: 473.55
• Mol File: 493005-73-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Methionine, N-[4-[[4-(4-nitrophenyl)-1-oxobutyl]amino]benzoyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Methionine, N-[4-[[4-(4-nitrophenyl)-1-oxobutyl]amino]benzoyl]-, methyl ester(493005-73-5)
• EPA Substance Registry System: L-Methionine, N-[4-[[4-(4-nitrophenyl)-1-oxobutyl]amino]benzoyl]-, methyl ester(493005-73-5)

Safety Data

• Hazardous Substances Data: 493005-73-5(Hazardous Substances Data)

Upstream product

• 5600-62-4 4-(4-nitrophenyl)butanoic acid 
• 5600-63-5 4-(4-nitrophenyl)butanoyl chloride 
• 154383-61-6 N-(4-aminobenzoyl)-L-methionine methyl ester 

Relevant articles and documents

Non-thiol farnesyltransferase inhibitors: Evaluation of different AA(X)-peptidomimetic substructures in combination with arylic cysteine replacements

In the course of our studies on non-thiol farnesyltransferase inhibitors based on the 2,5-diaminobenzophenone AAX-peptidomimetic substructure, we have developed the (4-nitrophenyl)butyryl (R1), the (2-naphthyl)acryloyl (R2), the 4-nitrocinnamoyl (R3), and the 5-(4-nitrophenyl)furylacryloyl (R4) groups as useful cysteine replacements. In this study, we combined these four groups with other AA(X)-peptidomimetic substructures (5-10: R = H) reported in the literature. The 5-(4-nitrophenyl)furylacryloyl moiety (R4) turned out to be the most useful non-thiol cysteine replacement yielding in all cases the most active inhibitors. By combination of this 5-(4-nitrophenyl)furylacryloyl moiety (R4) with the structurally simple AAX-peptidomimetics 4-aminobenzophenone (5) and 4-aminodiphenylsulfone (6) potent, readily accessible non-thiol farnesyltransferase inhibitors were obtained (IC50 = 12 nM and 10 nM).