4931-18-4 Usage
General Description
8-methyl-[1,2,4]triazolo[1,5-a]pyridine is a chemical compound with a molecular formula C7H7N3 and a molecular weight of 133.15 g/mol. It is a heterocyclic compound that consists of a pyridine ring fused with a triazolopyridine ring. 8-methyl-[1,2,4]triazolo[1,5-a]pyridine has potential applications in pharmaceuticals and agrochemicals due to its unique structure and properties. It may be used as a building block in the synthesis of various bioactive compounds and pharmaceutical drugs. Additionally, it may also have potential use as a pesticide or herbicide due to its heterocyclic nature and potential biological activity. Studies on the chemical, physical, and biological properties of 8-methyl-[1,2,4]triazolo[1,5-a]pyridine continue to be of interest to researchers in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 4931-18-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,3 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4931-18:
(6*4)+(5*9)+(4*3)+(3*1)+(2*1)+(1*8)=94
94 % 10 = 4
So 4931-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3/c1-6-3-2-4-10-7(6)8-5-9-10/h2-5H,1H3
4931-18-4Relevant articles and documents
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors with a Novel Monodentate Binding Interaction
Ahmed, Saleh,Ayscough, Andrew,Barker, Greg R.,Canning, Hannah E.,Davenport, Richard,Downham, Robert,Harrison, David,Jenkins, Kerry,Kinsella, Natasha,Livermore, David G.,Wright, Susanne,Ivetac, Anthony D.,Skene, Robert,Wilkens, Steven J.,Webster, Natalie A.,Hendrick, Alan G.
supporting information, p. 5663 - 5672 (2017/07/22)
Herein we describe the identification of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme. These inhibitors were shown to possess a novel binding mode by X-ray crystallography, in which the triazolo N1 atom coordinates in a hitherto unreported monodentate interaction with the active site Fe2+ ion, while the benzonitrile group accepts a hydrogen-bonding interaction from the side chain residue of Asn315. Further optimization led to potent PHD-1 inhibitors with good physicochemical and pharmacokinetic properties.
New Synthesis of s-Triazolopyridines and s-Triazoloisoquinoline
Lin, Yang-i,Lang, S.A.
, p. 3123 - 3124 (2007/10/02)
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