4942-85-2

Basic information

• Product Name: 2,3,6,7,12,12b-hexahydroindolo[2,3-a]quinolizin-4(1H)-one
• CAS NO: 4942-85-2
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.3003
• Mol File: 4942-85-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 486.3°C at 760 mmHg
• Flash Point: 247.9°C
• Density: 1.3g/cm³
• Vapor Pressure: 1.31E-09mmHg at 25°C
• Refractive Index: 1.689
• CAS DataBase Reference: 2,3,6,7,12,12b-hexahydroindolo[2,3-a]quinolizin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6,7,12,12b-hexahydroindolo[2,3-a]quinolizin-4(1H)-one(4942-85-2)
• EPA Substance Registry System: 2,3,6,7,12,12b-hexahydroindolo[2,3-a]quinolizin-4(1H)-one(4942-85-2)

Safety Data

• Hazardous Substances Data: 4942-85-2(Hazardous Substances Data)

Usage

Hexahydroindoloquinolizinone core

The compound has a complex molecular structure featuring a six-membered ring fused to a five-membered ring with a nitrogen atom.

Derivative of ergoline

It is a derivative of the naturally occurring alkaloid, ergoline.

Preccursor to psychoactive substances

It has been identified as a precursor to various psychoactive substances.

Serotonin receptor agonism

It exhibits potential biological activities, including serotonin receptor agonism.

Antipsychotic properties

It also has antipsychotic properties.

Interest in medicinal chemistry and drug discovery

Due to its unique structure and functional properties, it is of interest in the fields of medicinal chemistry and drug discovery.

Ongoing research

Further research into its pharmacological effects and potential therapeutic applications is ongoing.

Upstream product

• 76280-20-1 4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-3-carboxylic acid 
• 76280-18-7 (12bS)-Ethyl 4-oxo-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-3-carboxylate 
• 61-54-1 tryptamine 
• 201230-82-2 carbon monoxide 
• 1115302-72-1 N-[2-(1H-indol-3-yl)ethyl]but-3-enamide 
• 388091-45-0 2,5-dioxopyrrolidin-1-yl but-3-enoate 
• 340181-98-8 methyl 5-{[2-(1H-indol-3-yl)ethyl]amino}-5-oxopentanoate 
• 4787-24-0 methyl 4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)butanoate 
• 108-55-4 glutaric anhydride, 
• 91751-36-9 2,6,7,12-tetrahydroindolo[2,3-a]quinolizin-4(3H)-one 
• 56186-16-4 1-(2-(1H-indol-3-yl)ethyl)-5,6-dihydropyridin-2(1H)-one 

Downstream Products

• 4802-79-3 (5S,12bS)-1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinolizine 
• 84406-16-6 3,3-Bis-phenylsulfanyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one 
• 4802-79-3 1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine 
• 145471-63-2 4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine 
• 145471-67-6 C₂₈H₃₀N₂O₅S 
• 145471-64-3 4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine 
• 145471-62-1 4-oxo-3,3-bis(phenylthio)-12-(p-toluenesulfonyl)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine 
• 145471-66-5 C₃₄H₃₄N₂O₇S₂ 
• 145471-65-4 (4aR,13bS,14aR)-4a-Benzenesulfonyl-13-(toluene-4-sulfonyl)-4,4a,7,8,13,13b,14,14a-octahydro-1H,3H-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-2,5-dione 
• 145471-65-4 (4aR,13bR,14aR)-4a-Benzenesulfonyl-13-(toluene-4-sulfonyl)-4,4a,7,8,13,13b,14,14a-octahydro-1H,3H-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-2,5-dione 
• 483-29-4 (+/-)-3-epi-allo-yohimbone 

Relevant articles and documents

Bioinspired direct access to benzofuroindolines by oxidative [3 + 2] annulation of phenols and indoles

The straightforward entry to benzofuroindoline containing natural product-like scaffolds has been achieved by a challenging [3 + 2] oxidative coupling between phenols and indoles. The reaction proceeds by NIS-oxidation of the indole followed by the trapping of the resulting electrophilic intermediate by phenol.

Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**

A complementary dual carbonyl activation strategy for the synthesis of polycyclic alkaloids has been developed. Successful applications include the synthesis of tetracyclic alkaloids harmalanine and harmalacinine, pentacyclic indoloquinolizidine alkaloid nortetoyobyrine, and octacyclic β-carboline alkaloid peganumine A. The latter synthesis features a protecting-group-free assembly and an asymmetric disulfonimide-catalyzed cyclization. Furthermore, formal syntheses of hirsutine, deplancheine, 10-desbromoarborescidine A, and oxindole alkaloids rhynchophylline and isorhynchophylline have been achieved. Finally, a concise synthesis of berberine alkaloid ilicifoline B was completed.

NOVEL HDAC6 INHIBITORS AND THEIR USES

The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H ? L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).