494752-42-0 Usage
Description
Boronic acid, (4-amino-3-fluorophenyl)(9CI) is an organic compound characterized by the presence of a boron atom bonded to three hydroxyl groups and a 4-amino-3-fluorophenyl group. This unique structure endows it with specific chemical properties and reactivity, making it a versatile molecule for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
Boronic acid, (4-amino-3-fluorophenyl)(9CI) is used as a key intermediate in the synthesis of N-(phenyl)benzenesulfonamides. These compounds serve as GPR120 agonists, which are crucial for the treatment of GPR120-mediated diabetes. By modulating the GPR120 receptor, these agonists can help regulate insulin sensitivity and glucose metabolism, providing a potential therapeutic approach for managing diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 494752-42-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,4,7,5 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 494752-42:
(8*4)+(7*9)+(6*4)+(5*7)+(4*5)+(3*2)+(2*4)+(1*2)=190
190 % 10 = 0
So 494752-42-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H7BFNO2.ClH/c8-5-3-4(7(10)11)1-2-6(5)9;/h1-3,10-11H,9H2;1H
494752-42-0Relevant articles and documents
Synthesis and crystal structure of 4-amino-3-fluorophenylboronic acid
Das, Sasmita,Alexeev, Vladimir L.,Sharma, Anjal C.,Geib, Steven J.,Asher, Sanford A.
, p. 7719 - 7722 (2003)
4-Amino-3-fluorophenyl boronic acid has been synthesized from 4-bromo-2-fluoroaniline by protecting the amine group and then carrying out a lithium-bromine exchange, followed by addition of trimethyl borate and then acidic hydrolysis. We obtained a 47% yi
INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS
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Page/Page column 161; 162, (2008/06/13)
Disclosed are compounds having formula I and related compositions and methods thereof. The compounds are useful for treating viral infections caused by the Flaviviridae family of viruses.
