494803-05-3Relevant articles and documents
Asymmetric synthesis of aldol products derived from unsymmetrical ketones: Assignment of the absolute configuration of antibody aldol products
Maggiotti,Wong,Razet,Cowley,Gouverneur
, p. 1789 - 1798 (2007/10/03)
Compounds 1-7 are the products formed by aldol condensation of p-nitrobenzaldehyde with a series of unsymmetrical ketones, the reaction occurring at the less substituted carbon. The asymmetric synthesis of 1-7 using the Evans's asymmetric aldol methodology is described in detail. These syntheses were completed to allow us to assign the absolute configuration of products 1-3, obtained in a single step in the presence of the aldolase I antibody 84G3.