495414-64-7

Basic information

• Product Name: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID
• Synonyms: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID;1,4-Piperidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester;1-Boc-4-hydroxy-4-piperidine carbocylic acid;1-Boc-4-hydroxypiperidine-4-carboxylic acid
• CAS NO: 495414-64-7
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.27
• Mol File: 495414-64-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 398.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.275±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.77±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID(495414-64-7)
• EPA Substance Registry System: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID(495414-64-7)

Safety Data

• Hazardous Substances Data: 495414-64-7(Hazardous Substances Data)

Usage

Description

1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID, also known as 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic Acid, is an organic compound with the molecular formula C10H17NO5. It is a derivative of piperidine, a heterocyclic compound with potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID is used as a key intermediate in the synthesis of Lactam Oxaazaspiro compounds. These compounds are of significant interest in the pharmaceutical industry due to their potential therapeutic applications, particularly in the development of novel drugs targeting various diseases and conditions.
In the preparation of Lactam Oxaazaspiro compounds, 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID serves as a crucial building block, contributing to the structural diversity and potential biological activities of the final products. The synthesis of these compounds often involves complex chemical reactions, and the use of 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID allows for the creation of new molecular entities with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
The development of Lactam Oxaazaspiro compounds using 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID can lead to the discovery of innovative treatments for a wide range of medical conditions, including but not limited to cancer, neurological disorders, and infectious diseases. As a result, the use of this compound in the pharmaceutical industry is of great importance for the advancement of drug discovery and the improvement of human health.

Upstream product

• 495415-09-3 1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate 
• 1192189-92-6 1-tert-butyl 4-methyl 4-(2-methoxyethoxy)piperidine-1,4-dicarboxylate 

Relevant articles and documents

Preparation method of oxazaspiro compound

The invention discloses a preparation method of an oxazaspiro compound, which comprises the following steps: by using substituted saturated azaspiro alkane (compound II) as a raw material, performinghydrolyzing under an alkaline condition to obtain a compound III; carrying out condensation reaction on the compound III and a salt of a compound IV (halogenated alkylamine)/compound IV to generate acompound V; and finally, cyclizing the compound V under an alkaline condition to obtain the lactam oxazaspiro compound I.