4959-17-5

Basic information

• Product Name: 7-AMINOCLONAZEPAM
• Synonyms: 7-AMINOCLONAZEPAM;7-Amino-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one;7-Amino-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Aminoclonazepam;Chloraminazepam;Ro 5-461;2H-1,4-Benzodiazepin-2-one, 7-amino-5-(2-chlorophenyl)-1,3-dihydro-;7-AMINOCLONAZEPAM,1.0MG/MLINACETONITRILE
• CAS NO: 4959-17-5
• Molecular Formula: C₁₅H₁₂ClN₃O
• Molecular Weight: 285.73
• EINECS: 200-835-2
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles
• Mol File: 4959-17-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 226-228°C
• Boiling Point: 523.5 °C at 760 mmHg
• Flash Point: 2℃
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 4.69E-11mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: Controlled Substance, -20?C Freezer
• PKA: 12.15±0.70(Predicted)
• CAS DataBase Reference: 7-AMINOCLONAZEPAM(CAS DataBase Reference)
• NIST Chemistry Reference: 7-AMINOCLONAZEPAM(4959-17-5)
• EPA Substance Registry System: 7-AMINOCLONAZEPAM(4959-17-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37-26
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 4959-17-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

The major metabolite of Clonazepam (C587080).

InChI:InChI=1/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)

Upstream product

• 364046-84-4 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 10073-89-9 2-methyl-6-nitro-4H-benzo[d][1,3]oxazin-4-one 
• 2011-66-7 2'-chloro-5-nitro-2-aminobenzophenone 
• 52130-87-7 2-bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide 
• 17420-30-3 5-nitroanthranilonitrile 
• 3900-89-8 2-Chlorobenzeneboronic acid 

Relevant articles and documents

Novel method for preparing 7-amino clonazepam compound

The invention discloses a novel method for preparing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-amino-4-nitrobenzoic acid serves as an initial raw material, and a target compound is obtained through the processes of acetyl-lactonization, Grignard reaction, amide hydrolysis, intramolecular condensation reaction, reduction and the like. The method provided by the invention is safe to operate, avoids the use of heavy metals, is simple and convenient in post-treatment, can obtain the product through direct filtration and recrystallization, and does not need other purification. Only conventional acid, alkali and solvents are used in the whole reaction process, so that the method is less in environmental pollution, low in cost and higher in yield.

Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs

Human aldehyde oxidase 1 (AOX1) catalyzes the oxidation of various drugs and endogenous compounds. Recently, we found that AOX1 catalyzed the reduction of drugs such as nitrazepam and dantrolene. In this study, we aimed to clarify the substrate selectivit

REDUCTION OF NITRO DERIVATIVES OF 1,2-DIHYDRO-3H-1,4-BENZDIAZEPIN-2-ONES BY IMMOBILIZED CELLS OF E. coli

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