49616-71-9

Basic information

• Product Name: 2,4,6,8-TETRAMETHYLQUINOLINE
• Synonyms: 2,4,6,8-TETRAMETHYLQUINOLINE
• CAS NO: 49616-71-9
• Molecular Formula: C13H15N
• Molecular Weight: 185.26
• Mol File: 49616-71-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 284.499°C at 760 mmHg
• Flash Point: 124.321°C
• Appearance: /
• Density: 1.019g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2,4,6,8-TETRAMETHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6,8-TETRAMETHYLQUINOLINE(49616-71-9)
• EPA Substance Registry System: 2,4,6,8-TETRAMETHYLQUINOLINE(49616-71-9)

Safety Data

• Hazardous Substances Data: 49616-71-9(Hazardous Substances Data)

Usage

General Description

2,4,6,8-Tetramethylquinoline is a chemical compound with the molecular formula C13H15N. It is a yellow to brown crystalline solid that is soluble in organic solvents. 2,4,6,8-Tetramethylquinoline is primarily used as an intermediate in the production of dyes, pigments, and other organic compounds. It possesses antioxidant properties, and can be utilized as a stabilizer in rubber products and fuel oils to prevent degradation due to oxidation. 2,4,6,8-TETRAMETHYLQUINOLINE is also known for its use in the synthesis of luminescent materials and as a fluorescent probe in biological and environmental studies. Additionally, 2,4,6,8-Tetramethylquinoline is used in the manufacturing of pharmaceuticals and agrochemicals.

InChI:InChI=1/C13H15N/c1-8-5-10(3)13-12(6-8)9(2)7-11(4)14-13/h5-7H,1-4H3

Upstream product

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Relevant articles and documents

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-Activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogues resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 à 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and experimentally calculated IC50 values. Predicted binding orientation of the quinolinium analogues revealed selective binding to the NNMT substrate-binding site residues and essential chemical features driving protein-ligand intermolecular interactions and NNMT inhibition. The development of this new series of small molecule NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.