49619-59-2

Basic information

• Product Name: 5-Methoxy-4-oxo-4H-chroMene-3-carbaldehyde
• Synonyms: 5-Methoxy-4-oxo-4H-chroMene-3-carbaldehyde
• CAS NO: 49619-59-2
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.17882
• Mol File: 49619-59-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 366.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.401±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-Methoxy-4-oxo-4H-chroMene-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-4-oxo-4H-chroMene-3-carbaldehyde(49619-59-2)
• EPA Substance Registry System: 5-Methoxy-4-oxo-4H-chroMene-3-carbaldehyde(49619-59-2)

Safety Data

• Hazardous Substances Data: 49619-59-2(Hazardous Substances Data)

Upstream product

• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 699-83-2 2,6-dihydroxylacetophenone 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 62484-62-2 4-(5-methoxy-4-oxo-4H-chromen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 84531-15-7 4-(2-Hydroxy-4-methoxy-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 84531-12-4 4-(2-Hydroxy-6-methoxy-benzoyl)-6-(5-methoxy-4-oxo-4H-chromen-3-yl)-pyridine-2-carboxylic acid ethyl ester 
• 99488-23-0 4-(2-Hydroxy-6-methoxy-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 652968-78-0 (Z)-5-methoxy-4'-nitro-3-styrylchromone 
• 1160309-63-6 (E)-5-methoxy-3'-nitro-3-styrylchromone 
• 1307915-51-0 9-methoxy-10-oxo-3-phenyl-4a,10-dihydropyrano[4,3-b]chromene-4-carbaldehyde 
• 1422452-47-8 (E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-enyl)-5-methoxy-4H-chromen-4-one 
• 1422452-59-2 (E)-3-(3-hydroxy-3-(4-hydroxyphenyl)prop-1-enyl)-5-methoxy-4H-chromen-4-one 
• 1422452-73-0 (E)-5-methoxy-3-(3-(4-(4-methoxybenzyloxy)phenyl)-3-oxoprop-1-enyl)-4H-chromen-4-one 
• 1448991-92-1 dimethyl 3-(2-hydroxy-6-methoxybenzoyl)-6,7,12,12b-tetrahydroindolo[2,3-a]quinolizine-1,12b-dicarboxylate 

Relevant articles and documents

Synthesis of Chromeno[2,3-d]pyrimidin-5-one Derivatives from 1,3,5-Triazinanes via Two Different Reaction Pathways

1,3,5-Triazinanes, as a kind of versatile building block, are applied in the synthesis of chromeno[2,3-d]pyrimidin-5-one derivatives via two different reaction modes, which perfectly exhibits the powerful function of 1,3,5-triazinane as a three-atom synth

Direct construction of xanthene and benzophenone derivatives via Br?nsted acid controlled Diels-Alder reaction of 3-vinylchromones and arynes

A Br?nsted acid controlled Diels-Alder reaction of 3-vinylchromones with arynes has been developed. By employing different kinds and amounts of acid, 9-aryl-9H-xanthen-9-ols or ortho-hydroxybenzophenones could be controllably furnished in good yields in an atom- and step-economic manner.

Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression

A library of conjugates of chromones and 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C as a catalyst. Compounds 5c and 5e were most effective in lowering the blood glucose level comparable to standard drug pioglitazone. Compound 5e exhibited potent PPAR-γ transactivation of 48.72% in comparison to pioglitazone (62.48%). All the molecules showed good glide score against the PPAR-γ target in molecular docking study. PPAR-γ gene expression was significantly increased by compound 5e (2.56-fold) in comparison to standard drug pioglitazone. Compounds 5e and 5c did not cause any damage to the liver and may be considered as promising candidates for the development of new antidiabetic agents.