49621-50-3

Basic information

• Product Name: 3-(3,4,5-triMethoxyphenyl)propanenitrile
• Synonyms: 3-(3,4,5-triMethoxyphenyl)propanenitrile
• CAS NO: 49621-50-3
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• EINECS: -0
• Mol File: 49621-50-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3,4,5-triMethoxyphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4,5-triMethoxyphenyl)propanenitrile(49621-50-3)
• EPA Substance Registry System: 3-(3,4,5-triMethoxyphenyl)propanenitrile(49621-50-3)

Safety Data

• Hazardous Substances Data: 49621-50-3(Hazardous Substances Data)

Upstream product

• 49621-49-0 3,4,5-trimethoxycinnamyl nitrile 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 30077-81-7 2-(3,4,5-Trimethoxybenzyl)-3-morpholinoacrylonitrile 
• 30077-83-9 2-(3,4,5-Trimethoxybenzyl)-3-piperidinoacrylonitrile 
• 504408-39-3 4,4,4-trifluoro-3,3-dihydroxy-2-(3,4,5-trimethoxy-benzyl)-butyronitrile 
• 504408-41-7 3-ethoxy-4,4,4-trifluoro-2-(3',4',5'-trimethoxybenzyl)-but-2-enenitrile 
• 100252-79-7 3-(3,4,5-trimethoxyphenyl)propan-1-amine 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.