49643-99-4Relevant articles and documents
Microbiological Transformations. Part 4. Microbiological Transformations of 5α-Androstan-17-ones and of 17a-Aza-D-homo-5α-androstan-17-ones with the Fungus Cunninghamella elegans
Crabb, Trevor A.,Saul, John A.,Williams, Roger O.
, p. 1041 - 1045 (2007/10/02)
The microbiological transformation of 5α-androstan-17-one, and the 3β-acetoxy- and 3α-hydroxy-derivatives, by Cunninghamella elegans is dominated by 1β,7-dihydroxylation or 7-monohydroxylation. 3α-Acetoxy-5α-androstan-17-one undergoes predominant 6β,11β-dihydroxylation. 17a-Aza-D-homo-5α-androstan-17-one and the 3α-acetoxy-derivative undergo predominant monohydroxylation at 6β or 7α, in contrast to the 3β-acetoxy-derivative which, although undergoing similar monohydroxylation, gives good yield of 9α-monohydroxylated products.