49681-33-6 Usage
Description
N-(1-(naphthalen-1-yl)ethyl)forMaMide, also known as N-[1-(1-Naphthalenyl)ethyl]formamide, is a chemical compound derived from 1-Acetylnaphthalene (A186940). It is characterized by its naphthalene-based structure, which contributes to its unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
N-(1-(naphthalen-1-yl)ethyl)forMaMide is used as a synthetic intermediate for the preparation of S(-)-1-(1''-naphthyl) ethanol, which is an important compound in the synthesis of mevinic acid analogs. Mevinic acid analogs have potential applications in the development of pharmaceuticals targeting cholesterol synthesis and related conditions.
Used in Chemical Synthesis:
In the chemical industry, N-(1-(naphthalen-1-yl)ethyl)forMaMide serves as an intermediate in the preparation of (R)-(+)-1-(1-naphthyl)ethylamine, which is a key compound in the synthesis of cinacalcet. Cinacalcet is a drug used to treat secondary hyperparathyroidism in patients with chronic kidney disease, as well as primary hyperparathyroidism.
These applications highlight the versatility of N-(1-(naphthalen-1-yl)ethyl)forMaMide as a synthetic intermediate in the development of pharmaceuticals and other chemical products. Its unique structure and properties make it a valuable compound for researchers and chemists in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 49681-33-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,6,8 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 49681-33:
(7*4)+(6*9)+(5*6)+(4*8)+(3*1)+(2*3)+(1*3)=156
156 % 10 = 6
So 49681-33-6 is a valid CAS Registry Number.
49681-33-6Relevant articles and documents
Copper-Catalyzed Formylation of Amines by using Methanol as the C1 Source
Pichardo, Manuel Carmona,Tavakoli, Ghazal,Armstrong, Jessica E.,Wilczek, Tobias,Thomas, Bradley E.,Prechtl, Martin H. G.
, p. 882 - 887 (2020/02/11)
Cu/TEMPO catalyst systems are known for the selective transformation of alcohols to aldehydes, as well as for the simultaneous coupling of alcohols and amines to imines under oxidative conditions. In this study, such a Cu/TEMPO catalyst system is found to catalyze the N-formylation of a variety of amines by initial oxidative activation of methanol as the carbonyl source via formaldehyde and formation of N,O-hemiacetals and oxidation of the latter under very mild conditions. A vast range of amines, including aromatic and aliphatic, primary and secondary, and linear and cyclic amines are formylated under these conditions with good to excellent yields. Moreover, paraformaldehyde can be used instead of methanol for the N-formylation.
N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor
-
, (2008/06/13)
There is disclosed an N-(α-alkylbenzylidene)-α-phenylalkylamine represented by the general formula (1): STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X represents a halogen atom or a lower alkoxy group, its use and a process for producing the same and processes for producing intermediates therefor.
