496841-04-4

Basic information

• Product Name: L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI)
• Synonyms: L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI);(3S)-3-hydroxy-L-Proline Methyl ester;Methyl (3S)-3-hydroxy-L-prolinate
• CAS NO: 496841-04-4
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• Product Categories: CARBOXYLICESTER;ALCOHOL
• Mol File: 496841-04-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI)(496841-04-4)
• EPA Substance Registry System: L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI)(496841-04-4)

Safety Data

• Hazardous Substances Data: 496841-04-4(Hazardous Substances Data)

Usage

General Description

L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI) is a chemical compound that belongs to the proline family, which is an amino acid that is essential for the synthesis of proteins. In its methyl ester form, it is commonly used as a building block in the production of pharmaceuticals, agrochemicals, and other organic compounds. L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI) has a 3-hydroxy group, which makes it important for the formation of hydroxylated compounds. Its (3S) stereochemistry indicates that it has a specific three-dimensional arrangement of atoms, which affects its properties and reactivity. Overall, L-Proline, 3-hydroxy-, methyl ester, (3S)- (9CI) has a variety of important applications in the chemical and pharmaceutical industries.

Upstream product

• 67-56-1 methanol 
• 4298-08-2 trans-3-hydroxy-L-proline 
• 62182-54-1 (2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid 
• 14916-76-8 trans-3-Hydroxy-(L)-proline 

Downstream Products

• 412279-18-6 (2S,3S)-3-hydroxypyrrolidin-2-carboxamide 
• 184046-78-4 (2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate 
• 401909-57-7 (2S,3S)-1-(triphenylmethyl)-3-hydroxyproline methyl ester 
• 401909-77-1 3-methyl-1-trityl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 401909-59-9 (S)-3-Oxo-1-trityl-pyrrolidine-2-carboxylic acid methyl ester 
• 401909-65-7 3-phenyl-1-trityl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 401909-69-1 (S)-3-((E)-Hex-1-enyl)-1-trityl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 401909-61-3 (S)-methyl 3-(trifluoromethylsulfonyloxy)-1-trityl-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 657412-51-6 C₂₅H₂₃NO₃ 
• 942231-55-2 (2S,3S)-methyl 3-hydroxy-1-(4'-ethylbiphenylcarbonyl)pyrrolidine-2-carboxylate 
• 333969-68-9 methyl (2S,3S)-1-benzyl-3-hydroxypyrrolidine-2-carboxylate 
• 1374647-69-4 methyl (2S,3S)-1-benzyl-3-(tert-butyldiphenylsilyloxy)pyrrolidine-2-carboxylate 

Relevant articles and documents

Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones

Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents and the C8 position on the FQ core scaffold resulted in a remarkable enhancement of microbiological potency toward both Gram-positive and Gram-negative bacteria. Focused optimization of seven-membered ring composition, stereochemistry, and amine placement led to the discovery of the two lead compounds that were selected for further progression.

PYRAZOLINE DERIVATIVES AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I), in which the substituents are as defined in the specification; to compounds of formula (I) for use as androgen receptor modulators. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

L-Proline derived nitrogenous steroidal systems: An asymmetric approach to 14-azasteroids

An efficient chiral pool approach using l-proline to access 14-azasteroids under mild reaction conditions has been described. The key step involves the intramolecular SN2′ cyclization reaction for the construction of critical C-ring in the nitrogen impregnated steroidal architectures bearing unsaturation at Δ9(11) position. In the endeavour to synthesize some new congeners, the remote electronic impact of the electron donating groups in A ring and heteroatoms like oxygen in B ring, on the propensity of C-ring cyclization was also observed.