497177-66-9 Usage
Description
4-Piperidinamine, 1-(trifluoroacetyl)(9CI) is an organic compound with the molecular formula C6H10F3NO. It is a derivative of piperidine, featuring a trifluoroacetyl group attached to the 1-position. 4-Piperidinamine, 1-(trifluoroacetyl)(9CI) is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
4-Piperidinamine, 1-(trifluoroacetyl)(9CI) is used as a reactant in the preparation of naphthyridinones and related compounds. These compounds are of significant interest due to their antibacterial properties, making them valuable in the development of new antibiotics to combat drug-resistant bacterial infections.
As a key intermediate in the synthesis of various pharmaceutical compounds, 4-Piperidinamine, 1-(trifluoroacetyl)(9CI) plays a crucial role in the development of novel drugs with improved efficacy and reduced side effects. Its unique structure allows for the creation of a wide range of derivatives, which can be tailored to target specific biological pathways and receptors, potentially leading to more effective treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 497177-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,7,1,7 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 497177-66:
(8*4)+(7*9)+(6*7)+(5*1)+(4*7)+(3*7)+(2*6)+(1*6)=209
209 % 10 = 9
So 497177-66-9 is a valid CAS Registry Number.
497177-66-9Relevant articles and documents
Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity
Zhou, Jie,Ji, Ming,Zhu, Zhixiang,Cao, Ran,Chen, Xiaoguang,Xu, Bailing
, p. 26 - 41 (2017/03/23)
Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.