497261-38-8Relevant articles and documents
Design and synthesis of some novel 2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as potential c-Met inhibitors
Ye, Lianbao,Tian, Yuanxin,Li, Zhonghuang,Zhang, Jiajie,Wu, Shuguang
, p. 320 - 326 (2012)
Since deregulation of the tyrosine-kinase receptor c-Met is implicated in several human cancers and is an attractive target for small-molecule-drug discovery, we report herein the synthesis of 2,3,4,5-tetrahydro-8-[1-(quinolin- 6-ylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrido[4,3-b]indoles 4a-4c and 2,3,4,5-tetrahydro-8-[3-(quinolin-6-ylmethyl)-1,2,4-triazolo[4,3-b] pyridazin-6-yl]-1H-pyrido[4,3-b]indoles 5a-5c. These indole derivatives demonstrated inhibition of c-Met kinase activity. Concurrently, five key intermediates were synthesized. These compounds could be prepared in good yields. Copyright
Functionalized tetrahydro-1 H-pyrido[4,3-b]indoles: A novel chemotype with Sirtuin 2 inhibitory activity
Yang, Tianming,Chen, Xiao,Jin, Hai-Xiao,Sethi, Gautam,Go, Mei-Lin
, p. 145 - 155 (2015)
Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in vitro inhibitory potencies in the low micromolar conce
FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 113; 114, (2008/06/13)
Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.