49761-04-8

Basic information

• Product Name: L-Proline, 1-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-, methyl ester
• CAS NO: 49761-04-8
• Molecular Formula: C20H28N2O5
• Molecular Weight: 376.453
• Mol File: 49761-04-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-, methyl ester(49761-04-8)
• EPA Substance Registry System: L-Proline, 1-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-, methyl ester(49761-04-8)

Safety Data

• Hazardous Substances Data: 49761-04-8(Hazardous Substances Data)

Upstream product

• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 2018-66-8 N-(Benzyloxycarbonyl)-L-leucine 
• 2018-66-8 2-Benzyloxycarbonylamino-4-methyl-pentanoic acid 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 
• 53363-87-4 N-(benzyloxycarbonyl)leucine dicyclohexylamine salt 
• 1738-87-0 Z-Leu-ONp 
• 2018-66-8 Z-Leu-OH 

Downstream Products

• 2873-36-1 cyclo(L-Pro-L-Leu) 
• 1072102-31-8 (3S,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine 
• 126587-62-0 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4- 
• 126587-64-2 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2- 
• 1053630-19-5 C₆₆H₁₀₇N₅O₁₆Si 
• 126587-63-1 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop 
• 148339-15-5 C₅₈H₁₀₁N₅O₁₅Si 
• 126587-61-9 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine-OSEM 
• 129919-84-2 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine 
• 138541-24-9 H-L-Leu-L-Pro-L-Ser(tBu)-OPh*TosOH 
• 138541-04-5 Z-L-Leu-L-Pro-L-Ser(tBu)-OPh 
• 138541-20-5 Z-L-Leu-L-Pro-L-Ser(tBu)-OMe 
• 138541-21-6 Z-L-Leu-L-Pro-L-Ser(tBu)-OH 
• 74992-62-4 (S)-1-(2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid 4-nitro-phenyl ester 

Relevant articles and documents

Comparative study of selected coupling reagents in dipeptide synthesis

A comparative study of the effectiveness of selected coupling reagents in dipeptide synthesis was conducted. Included in the study were a new coupling agent, pentafluorophenyl diphenylphosphinate (FDPP, 1), benzotriazol-1-yl-oxytris(dimethylamino)phosphon

KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS

The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.

Exceptional Micellar Stereoselectivity in Esterolysis Reactions: The Micelle-Enzyme Analogy

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