497831-42-2

Basic information

• Product Name: C₄₃H₇₄N₂O₁₂
• Synonyms: C₄₃H₇₄N₂O₁₂
• CAS NO: 497831-42-2
• Molecular Weight: 811.067
• Mol File: 497831-42-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₃H₇₄N₂O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₇₄N₂O₁₂(497831-42-2)
• EPA Substance Registry System: C₄₃H₇₄N₂O₁₂(497831-42-2)

Safety Data

• Hazardous Substances Data: 497831-42-2(Hazardous Substances Data)

Upstream product

• 63864-45-9 (9S)-9-dihydroerythromycin A 
• 61248-83-7 (2R)-1-amino-3-(benzyloxy)propan-2-ol 
• 14618-80-5 (R)-benzyl glycidol 
• 1262535-97-6 C₅₅H₁₀₉NO₁₃Si₃ 
• 1262536-16-2 C₆₁H₁₁₆N₂O₁₂Si₃ 
• 1262536-12-8 C₆₁H₁₁₈N₂O₁₃Si₃ 
• 497832-22-1 (9S)-9,2',4''-O-tris(triethylsilyl)-9-dihydroerythromycin A 

Relevant articles and documents

Synthesis and antibacterial activity of a novel class of 15-membered macrolide antibiotics, "11a-Azalides"

An efficient method for the reconstruction of the 9-dihydroerythromycin A macrolactone skeleton has been established. The key steps are oxidative cleavage at the 11,12-position and reconstruction after insertion of an appropriate functionalized amino alcohol. Novel 15-membered macrolides, we named as "11a-azalides", were synthesized based on the above methodology and evaluated for their antibacterial activity. Among them, (13R)-benzyloxymethyl- 11a-azalide showed the most potent Streptococcus pneumoniae activity, with improved activity against a representative erythromycin-resistant strain compared to clarithromycin (CAM).