497956-85-1

Basic information

• Product Name: Benzenamine, N-methyl-N-[2-methyl-1-[(trimethylsilyl)oxy]-1-propenyl]-
• CAS NO: 497956-85-1
• Molecular Formula: C14H23NOSi
• Molecular Weight: 249.428
• Mol File: 497956-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-methyl-N-[2-methyl-1-[(trimethylsilyl)oxy]-1-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-methyl-N-[2-methyl-1-[(trimethylsilyl)oxy]-1-propenyl]-(497956-85-1)
• EPA Substance Registry System: Benzenamine, N-methyl-N-[2-methyl-1-[(trimethylsilyl)oxy]-1-propenyl]-(497956-85-1)

Safety Data

• Hazardous Substances Data: 497956-85-1(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 55577-65-6 2,N-dimethyl-N-phenylpropanamide 

Downstream Products

• 1217744-90-5 C₁₈H₁₄F₇NO 
• 1217744-91-6 C₁₅H₁₉F₂NO₃ 
• 1217744-88-1 C₂₁H₁₄F₂₁NO 
• 1217744-85-8 C₁₅H₁₄F₉NO 

Relevant articles and documents

Mechanistic studies on α-trifluoromethylation of ketones via silyl enol ethers and its application to other carbonyl compounds

(Chemical Equation Presented) Synthesis of α-CF3 carbonyl compounds has been recognized to be difficult up to now because the polarization of CF3δ--Iδ+ is opposite to that of CH3δ+-Iδ-, and this makes it difficult to introduce CF3+ unit to enolates. We recently reported an effective R-trifluoromethylation of ketones by using Et 2Zn with Rh catalyst, but the mechanism has not fully been cleared. Now, we carried out the detailed mechanistic studies and found the involvement of a highly reactive alkylrhodium complex which derived from Et2Zn and RhCl(PPh3)3 in this α-trifluoromethylation. Furthermore, this α-trifluoromethylation was applied to other types of carbonyl compounds in good yields.