498-46-4 Usage
Description
(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol, also known as Isoscopine, is a chemical compound derived from Scopine (S199975), which is an intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator. It is a tricyclic compound with a unique molecular structure that has potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol is used as an intermediate in the production of Tiotropium Bromide for the pharmaceutical industry. Tiotropium Bromide is a long-acting bronchodilator that helps in treating chronic obstructive pulmonary disease (COPD) and other respiratory conditions by relaxing the muscles in the airways and improving breathing.
Used in Chemical Synthesis:
(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol can be used as a starting material or a building block in the synthesis of other complex organic compounds. Its unique molecular structure and functional groups make it a valuable component in the development of new pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Research and Development:
As a derivative of Scopine, (1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol can be utilized in research and development for understanding its chemical properties, reactivity, and potential applications in various fields. Researchers can explore its use in the synthesis of novel compounds, study its interactions with biological systems, or investigate its potential as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 498-46-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 498-46:
(5*4)+(4*9)+(3*8)+(2*4)+(1*6)=94
94 % 10 = 4
So 498-46-4 is a valid CAS Registry Number.
498-46-4Relevant articles and documents
Total synthesis of scopine, pseudoscopine, and nor-derivatives
Justice, David E.,Malpass, John R.
, p. 11977 - 11994 (2007/10/03)
Scopine and pseudoscopine have been synthesised from cyclohepta-3,5-dienol; the initial 1,4-functionalisation of the diene is based on a nitroso- cycloaddition. The use of the N-benzyloxycarbonyl group throughout the scheme allows ultimate reductive deprotection to yield N-methyl or novel NH (nor-) derivatives without damage to the exo-epoxide of the title compounds. Preliminary investigation of nitroso- cycloaddition to 5,6-epoxycyclohepta-1,3-diene is described.
Stereocontrolled Epoxidations of Cycloheptene Derivatives in the Palladium-Catalyzed Route to Tropane Alkaloids. Total Syntheses of Scopine and Pseudoscopine
Schink, Hans E.,Pettersson, Helena,Baeckvall, Jan-E.
, p. 2769 - 2774 (2007/10/02)
Stereoselective total syntheses of the tropane alkaloids scopine (1) and pseudoscopine (3) have been developed via the chloroacetoxylation approach.Palladium-catalyzed 1,4-chloroacetoxylation of diene 6 afforded the key intermediate 7.Subsequent substitution of the allylic chloride by TsNH- with either retention (Pd(0) catalysis) or inversion (SN2) of configuration gave 10 and 16, respectively.The epoxy oxygen was introduced syn to the nitrogen function prior to cyclization by utilizing the syn-directive effect of the allylic sulfonamido group in the epoxidation.Cyclization of the epoxides 12 and 21, followed by replacement of the tosyl group by a methyl group and subsequent debenzylation, afforded the title compounds 1 and 3, respectively.
