498573-81-2

Basic information

• Product Name: (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE
• Synonyms: (S)-TETRAHYDROFURAN-2-CARBOXAMIDE;(S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE
• CAS NO: 498573-81-2
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• Product Categories: Amides;Chiral Compounds;Chiral Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 498573-81-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 82-86 °C(lit.)
• Boiling Point: 305.7 °C at 760 mmHg
• Flash Point: 198.8 °C
• Appearance: /
• Density: 1.172 g/cm³
• PKA: 15.50±0.20(Predicted)
• CAS DataBase Reference: (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE(498573-81-2)
• EPA Substance Registry System: (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE(498573-81-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 498573-81-2(Hazardous Substances Data)

Usage

Description

(S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is an organic compound that serves as a crucial intermediate in the synthesis of various chemical products. It is characterized by its unique chemical structure, which includes a tetrahydrofuran ring and a carboxamide functional group. (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is known for its potential applications in the pharmaceutical and chemical industries due to its ability to be transformed into other valuable compounds through chemical reactions.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is used as a precursor for the preparation of (S)-tetrahydrofuran-2-carbonitrile (THFCN) via a dehydration reaction using thionyl chloride and DMF. This transformation is essential in the synthesis of various pharmaceutical compounds, as THFCN can be further modified to produce a range of biologically active molecules.
Used in Chemical Synthesis:
In the chemical synthesis industry, (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is used as a starting material for the production of (S)-1-(tetrahydrofuran-2-yl)ethenone. (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is achieved by methylating THFCN with methylmagnesium chloride (Grignard reagent). The resulting product, (S)-1-(tetrahydrofuran-2-yl)ethenone, is a valuable building block for the synthesis of various organic compounds, including those with potential applications in materials science and specialty chemicals.
Overall, (S)-(-)-TETRAHYDROFURAN-2-CARBOXYLIC ACID AMIDE is a versatile compound with significant applications in both the pharmaceutical and chemical synthesis industries. Its ability to be transformed into a variety of other compounds makes it a valuable asset in the development of new drugs, materials, and other chemical products.

Downstream Products

• 539820-24-1 (S)-tetrahydrofuran-2-carbonitrile