499140-47-5

Basic information

• Product Name: 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)
• Synonyms: 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)
• CAS NO: 499140-47-5
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.23
• Product Categories: ETHYL
• Mol File: 499140-47-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 327.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 5.55±0.10(Predicted)
• CAS DataBase Reference: 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)(499140-47-5)
• EPA Substance Registry System: 2(5H)-Furanone,5-ethyl-4-hydroxy-5-methyl-3-(1-methylethoxy)-,(5S)-(9CI)(499140-47-5)

Safety Data

• Hazardous Substances Data: 499140-47-5(Hazardous Substances Data)

Upstream product

• 208117-20-8 methyl (2S)-2-hydroxy-2-methylbutanoate 
• 37505-07-0 (S)-2-hydroxy-2-methylbutyric acid 
• 499140-46-4 (S)-methyl 2-methyl-2-[2-(1-methylethoxy)acetyloxy]butanoate 

Downstream Products

• 499140-48-6 (S)-5-ethyl-5-methyl-3-(1-methylethoxy)-4-(4-(methylthio)phenyl)-3-oxolen-2-one 
• 189954-93-6 (S)-5-ethyl-5-methyl-3-(1-methylethoxy)-4-[(4-methylsulfonyl)phenyl]-3-oxolen-2-one 

Relevant articles and documents

Practical enantioselective synthesis of a COX-2 specific inhibitor

Two synthetic strategies to the COX-2 specific inhibitor 1 have been described that allowed its preparation in large quantities in 79% overall yield from (S)-2-hydroxy-2-methylbutyric acid. These studies have led to the identification of an efficient resolution of (±)-2-hydroxy-2-methylbutyric acid and a novel thionyl chloride aided formation of amide 11 from acid 6.