4992-02-3

Basic information

• Product Name: 2-[(diethylamino)methyl]phenol
• Synonyms: phenol, 2-[(diethylamino)methyl]-
• CAS NO: 4992-02-3
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.2588
• Mol File: 4992-02-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 255°C at 760 mmHg
• Flash Point: 99.6°C
• Density: 1.01g/cm³
• Vapor Pressure: 0.0105mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 2-[(diethylamino)methyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(diethylamino)methyl]phenol(4992-02-3)
• EPA Substance Registry System: 2-[(diethylamino)methyl]phenol(4992-02-3)

Safety Data

• Hazardous Substances Data: 4992-02-3(Hazardous Substances Data)

Usage

Chemical structure

Phenolic structure with a diethylamino methyl group attached to the aromatic ring.

Usage

Local anesthetic, antiseptic.

Applications

Topical pain relief creams and ointments, antiseptic mouthwashes, and throat lozenges.

Benefits

Provides temporary relief from minor skin irritations and pains, prevents the growth of bacteria and fungi on the skin and mucous membranes.

Caution

Use with caution and under the guidance of a medical professional to avoid potential adverse effects.

Upstream product

• 50-00-0 formaldehyd 
• 109-89-7 diethylamine 
• 108-95-2 phenol 
• 19311-91-2 N,N-diethylsalicylamide 
• 6161-96-2 2-acetoxymethylphenol 
• 7732-18-5 water 
• 27958-81-2 diethyl(ortho-methoxybenzyl)amine 
• 74-95-3 1,1-dibromomethane 
• 98-80-6 phenylboronic acid 

Downstream Products

• 103326-69-8 1,7-bis-(2-diethylaminomethyl-phenoxy)-heptane 
• 70538-73-7 (2-Hydroxy-benzyl)-phosphonothioic acid O,O-diethyl ester 
• 90-01-7 salicylic alcohol 

Relevant articles and documents

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The modified-Mannich reaction: Conversion of arylboronic acids and subsequent coupling with paraformaldehyde and amines toward the one-pot synthesis of Mannich bases and benzoxazines

A modified Mannich reaction has been developed for the synthesis of Mannich bases and benzoxazines via the oxidative hydroxylation of arylboronic acids and subsequent coupling with paraformaldehyde and amines in one pot. This modified Mannich reaction is easily carried out to afford the target products in good to excellent yields and tolerates a variety of functional groups.

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U