500-08-3

Basic information

• Product Name: Forminitrazole
• Synonyms: Forminitrazole;N-(5-Nitrothiazol-2-yl)formamide;N-(5-nitro-1,3-thiazol-2-yl)formamide;N-(5-nitro-1,3-thiazol-2-yl)methanamide
• CAS NO: 500-08-3
• Molecular Formula: C4H3 N3 O3 S
• Molecular Weight: 173.15
• Mol File: 500-08-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 355.8°Cat760mmHg
• Flash Point: 169°C
• Appearance: /
• Density: 1.718g/cm³
• Vapor Pressure: 3.05E-05mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: Forminitrazole(CAS DataBase Reference)
• NIST Chemistry Reference: Forminitrazole(500-08-3)
• EPA Substance Registry System: Forminitrazole(500-08-3)

Safety Data

• Hazardous Substances Data: 500-08-3(Hazardous Substances Data)

Usage

General Description

Forminitrazole is a chemical compound with the molecular formula C2H3N4O2. It is an organic compound and a derivative of imidazole and nitric acid. Forminitrazole is used as a precursor in the synthesis of pharmaceuticals and other organic compounds. It has a wide range of applications in the pharmaceutical and chemical industries, particularly in the production of nitric oxide donating drugs and in the formation of metal complexes for biological studies. Forminitrazole is known for its high reactivity and stability, making it a valuable compound in various chemical processes.

InChI:InChI=1/C4H3N3O3S/c8-2-6-4-5-1-3(11-4)7(9)10/h1-2H,(H,5,6,8)

Upstream product

• 64-18-6 formic acid 
• 121-66-4 2-amino-5-nitro-1,3-thiazole 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 50384-48-0 N-formyl-N-(5-nitro-thiazol-2-yl)-glycine dipropylamide 
• 43152-40-5 [N-formyl-N-(5-nitro-thiazol-2-yl)-glycyl]-methyl-carbamic acid ethyl ester 
• 50384-56-0 benzyl-[N-formyl-N-(5-nitro-thiazol-2-yl)-glycyl]-carbamic acid ethyl ester 
• 50384-50-4 N-formyl-N-(5-nitro-thiazol-2-yl)-glycine benzylamide 

Relevant articles and documents

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e.g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule libraries for initial in vitro evaluation, as radiolabeling has to be optimized for each individual molecule. The present paper discloses a method for preparing libraries of 18F-labeled radiopharmaceuticals using both the fluorous-based 18F-radiochemistry and the Huisgen 1,3-dipolar (click) conjugation reaction. As a proof of concept, this approach allowed us to obtain a series of readily accessible 18F-radiolabeled nitroaromatic molecules, for exploring their structure-activity relationship and further in vitro evaluation of their hypoxic selectivity.