500-88-9

Basic information

• Product Name: Benzenepropanol,â-amino-4-hydroxy-
• Synonyms: 4-((S)-2-Amino-3-hydroxy-propyl)-phenol;DL-2-Amino-3-(4-hydroxy-phenyl)-propan-1-ol;(+-)-2-amino-3-(4-hydroxy-phenyl)-propan-1-ol;(+/-)-2-amino-3-(4-hydroxyphenyl)-1-propanol;DL-Tyrosinol;'DL-Tyrosinol'
• CAS NO: 500-88-9
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Mol File: 500-88-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 91.4-92.1 °C
• Boiling Point: 170-180 °C(Press: 0.05 Torr)
• Density: 1.205±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepropanol,â-amino-4-hydroxy- (CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol,â-amino-4-hydroxy- (500-88-9)
• EPA Substance Registry System: Benzenepropanol,â-amino-4-hydroxy- (500-88-9)

Safety Data

• Hazardous Substances Data: 500-88-9(Hazardous Substances Data)

Upstream product

• 5619-08-9 tyrosine ethyl ester hydrochloride 
• 98-86-2 acetophenone 
• 5441-51-0 4-ethylcyclohexanone 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 4276-17-9 methyl (N-benzoyl)-4'-hydroxyphenylalaninate 
• 34996-91-3 N-benzoyl-(4'-hydroxy)phenylalanine 
• 3417-91-2 tyrosine methyl ester hydrochloride 
• 94460-79-4 DL-2-Benzamino-3-(4-hydroxy-phenyl)-propan-1-ol; 'N-Benzoyl-DL-tyrosinol' 

Downstream Products

• 344359-49-5 2-amino-1-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-4-phenyl-1H-pyrrole-3-carbonitrile 
• 344427-67-4 N-{3-cyano-1-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-4-phenyl-1H-pyrrol-2-yl}-formamidine 
• 60142-69-0 N-(2-methylbenzyloxycarbonyl)-tyrosinol 
• 344359-41-7 2-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethylamino]-1-phenyl-ethanone 
• 184592-32-3 4-(2-Dimethylamino-3-hydroxy-propyl)-phenol 

Relevant articles and documents

N-Substituted Benzenepropanamide and Benzenepropenamide For Use in the Prevention or the Treatment of Affective Disorders

Compounds for use in the treatment or prophylaxis of an affective disorder, which compound is represented by formula I in which the dotted line represents a single or a double bond; and R5 and R5′ are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is —CH2O—; Z is —CH2OH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is 1; and n is an integer of 1-5; or a pharmaceutically acceptable salt, prodrug, metabolite, or hydrate thereof.

Asymmetric microbial reduction of ketones: absolute configuration of trans-4-ethyl-1-(1S-hydroxyethyl)cyclohexanol

A set of five fungal species, Botrytis cinerea, Trichoderma viride and Eutypa lata, and the endophytic fungi Colletotrichum crassipes and Xylaria sp., was used in screening for microbial biocatalysts to detect monooxygenase and alcohol dehydrogenase activities (for the stereoselective reduction of carbonyl compounds). 4-Ethylcyclohexanone and acetophenone were biotransformed by the fungal set. The main reaction pathways involved reduction and hydroxylations at several positions including tertiary carbons. B. cinerea was very effective in the bioreduction of both substrates leading to the chiral alcohol (S)-1-phenylethanol in up to 90% enantiomeric excess, and the cis-trans ratio for 4-ethylcyclohexanol was 0:100. trans-4-Ethyl-1-(1S-hydroxyethyl)cyclohexanol, obtained from biotransformation by means of an acyloin-type reaction, is reported here for the first time. The absolute configurations of the compounds trans-4-ethyl-1-(1S-hydroxyethyl)cyclohexanol and 4-(1S- and 4-(1R-hydroxyethyl)cyclohexanone were determined by NMR analysis of the corresponding Mosher's esters.

NOVEL COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES, IMMUNO-ALLERGICAL DISEASES AND ORGAN OR TISSUE TRANSPLANTATION REJECTION

The present invention provides compounds, pharmaceutical compositions and methods for treating, immuno-allergical diseases, autoimmune diseases, and organ or tissue rejection following transplantation.