500018-96-2Relevant articles and documents
Photoredox-Catalyzed Deformylative 1,4-Addition of 2′-Deoxy-5′- O-phthalimidonucleosides for Synthesis of 5′-Carba Analogs of Nucleoside 5′-Phosphates
Ito, Yuta,Kimura, Airi,Osawa, Takashi,Hari, Yoshiyuki
, p. 10701 - 10708 (2018/09/21)
A concise approach for the synthesis of the 5′-carba analogs of nucleoside 5′-phosphates from 2′-deoxy-5′-O-phthalimidonucleosides by a visible-light-mediated deformylative 1,4-addition was developed. This method enabled rapid and facile generation of 4′-carbon radicals of nucleosides. Moreover, this synthetic strategy was applicable to the 5′-carba analogs of nucleoside 5′-phosphates as well as other 5′-carba nucleosides bearing methoxycarbonyl, cyano, and N-methylsulfamoyl groups.