500021-58-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-[[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-
• CAS NO: 500021-58-9
• Molecular Formula: C25H31F3N2O4
• Molecular Weight: 480.527
• Mol File: 500021-58-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(500021-58-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-(500021-58-9)

Safety Data

• Hazardous Substances Data: 500021-58-9(Hazardous Substances Data)

Upstream product

• 250589-63-0 (2S,3R)-tert-butyl 3-hydroxy-2-phenylpiperidine-1-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-58-3 phenylmagnesium bromide 
• 187679-58-9 (2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine 
• 500021-57-8 (S)-3-[(E)-Methoxyimino]-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 191669-62-2 (S)-tert-butyl 3-carbonyl-2-phenylpiperidine-1-carboxylic acid 
• 145742-65-0 2-methoxy-5-(trifluoromethoxy)benzaldehyde 

Downstream Products

• 145742-28-5 (2S,3S)-3-(2-methoxy-5-trifluoromethoxybenzyl)-amino-2-phenylpiperidine 

Relevant articles and documents

Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization

An efficient diastereoselective approach to access trans-5-hydroxy-6-substituted 2-piperidinones skeleton has been developed through one-pot intramolecular tandem process of O-benzyl protected aldimine 11 with Grignard reagents. The diastereoselectivity of substitution at C-6 position of 2-piperidinone was controlled by α-benzyloxy group. In addition, the utility of this straightforward cascade process is demonstrated by the asymmetric syntheses of (+)-L-733, 060 (2) and its 2-substituted analogue 3, as well as (+)-CP-122721 (5).

Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of