500131-75-9Relevant articles and documents
Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy
Pave, Gregoire,Leger, Jean-Michel,Jarry, Christian,Viaud-Massuard, Marie-Claude,Guillaumet, Gerald
, p. 1401 - 1408 (2007/10/03)
Enantiomerically pure (3′R)- and (3′S)-3′,4′-dihydrospiro[piperidine-2,3′ (2′H)-benzopyran]s (R)-10 and (S)-10 were successfully synthesized according to the CN(R,S) methodology with the aim of serving as a pattern for the generation of related spirocyclic compounds. Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (-)-2. One of them was selected and used for the preparation of amines (R)-17 and (S)-17 starting from (-)-2 and (+)-2, respectively. The enantiomeric purity of all final aminochroman derivatives was determinated by capillary electrophoresis using β-cyclodextrin as the chiral selector.