500297-82-5Relevant articles and documents
Synthesis and derivatization of ethynyl α,α-dibromomethyl ketones: Formation of highly functionalized vinyl triflates
Rankin, Trent,Tykwinski, Rik R.
, p. 213 - 216 (2007/10/03)
(Matrix presented) We describe the synthesis of α,α -dibromomethyl ynones (8) and their subsequent derivatization to vinyl acetates (10). These vinyl acetates feature a 1,1-dibromo-olefin moiety, which is readily exploited in palladium-catalyzed Sonogashira, Stille, and Suzuki cross-coupling reactions with alkynes, stannanes, and boronic acids, respectively. A novel one-pot process then directly converts the resulting vinyl acetates 11-13 to the vinyl triflate derivatives 14a-j.