5005-38-9Relevant articles and documents
Anti-viral method
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, (2008/06/13)
PCT No. PCT/US97/07431 Sec. 371 Date Jan. 6, 1999 Sec. 102(e) Date Jan. 6, 1999 PCT Filed May 2, 1997 PCT Pub. No. WO97/41846 PCT Pub. Date Nov. 13, 1997The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
Reaction of pyridinium salts with active methylene group: Part I - Synthesis of 4-substituted 1,4-dihydropyridine derivatives
Fadda, A A
, p. 834 - 838 (2007/10/02)
The active methylene group in acetonitriles of the type CH2YZ (Y=CN, Z=R or Ar) (II) undergoes condensation readily with pyridinium salts (Ia-d) to yield 4-substituted 1,4-dihydropyridines.The active methylene group present in the thiazolidone (XIV) and oxazolone (XV) rings also react with 1 to give the corresponding 1,4-dihydro(thiazolono)-pyridines.
A New Synthesis of Aryl Hetaryl Ketones via SRN1 Reaction of Halogenated Heterocycles withPotassiophenylacetonitrile Followed by Phase-Transfer Catalyzed Decyanation
Hermann, Christine K. F.,Sachdeva, Yesh P.,Wolfe, James F.
, p. 1061 - 1065 (2007/10/02)
Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.