500732-79-6Relevant articles and documents
Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter
Provencher, Brian A.,Eshleman, Amy J.,Johnson, Robert A.,Shi, Xiao,Kryatova, Olga,Nelson, Jared,Tian, Jianhua,Gonzalez, Mario,Meltzer, Peter C.,Janowsky, Aaron
supporting information, p. 9121 - 9131 (2018/10/20)
Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increase ex
SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 65-66, (2008/12/04)
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I).
Coupling reactions of α-(N-Carbamoyl)alkylcuprates with enol triflates derived from cyclic β-keto esters: A facile approach to γ-carbamoyl-α,β-enoates
Li, ShengJian,Dieter, R.Karl
, p. 969 - 973 (2007/10/03)
α-(N-Carbamoylalkyl)cuprates couple with enol triflates derived from carbocyclic and heterocyclic (i.e., piperidinones) β-keto esters. Product yields are higher with the alkyl(cyano)cuprates [i.e., RCu-(CN)Li, 56-93%] than with the dialkylcuprate reagents (i.e., R2CuLi·LiCN). An enol nonaflate works as well as the corresponding enol triflate. A facile synthetic route to γ-amino α,β-enoates not readily prepared from γ-keto-α,β-enoates is thus established. The γ-amino-α,β-enoates, available via N-Boc deprotection, can be cyclized to annulated pyrrolin-2-ones.