500767-10-2

Basic information

• Product Name: (2S)-2-amino-3-(4-bromophenyl)propanamide
• Synonyms: (2S)-2-amino-3-(4-bromophenyl)propanamide
• CAS NO: 500767-10-2
• Molecular Weight: 243.103
• Mol File: 500767-10-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2S)-2-amino-3-(4-bromophenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-3-(4-bromophenyl)propanamide(500767-10-2)
• EPA Substance Registry System: (2S)-2-amino-3-(4-bromophenyl)propanamide(500767-10-2)

Safety Data

• Hazardous Substances Data: 500767-10-2(Hazardous Substances Data)

Upstream product

• 869569-99-3 tert-butyl (S)-(1-amino-3-(4-bromophenyl)-1-oxopropan-2-yl)carbamate 
• 62129-39-9 4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine 
• 24250-84-8 H-p-BrPhe-OH 
• 99359-33-8 (S)-methyl 2-amino-3-(4-bromophenyl)propanoate 

Downstream Products

• 1428667-51-9 C₂₈H₂₉FN₄O₃ 
• 1428666-31-2 (1R,3S,4S)-tert-butyl 3-((S)-2-(4-bromophenyl)-1-cyanoethylcarbamoyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1428666-32-3 (1R,3S,4S)-tert-butyl 3-((S)-1-cyano-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamoyl)-2-azabicyclo [2.2.1]heptane-2-carboxylate 
• 1428666-30-1 C₂₁H₂₈BrN₃O₄ 
• 558467-56-4 (2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-2-(p-bromobenzyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-7-phenylheptanoyl amide 
• 500767-08-8 Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-5-(4-bromo-benzyl)-2,4-dioxo-imidazolidin-1-yl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide 
• 500767-24-8 (2S,5S,6S)-3-aza-3-(benzyloxycarbonyl)-2-(p-bromobenzyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide 
• 500767-38-4 Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-2-(4-bromo-phenyl)-1-carbamoyl-ethylamino]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide 
• 500767-17-9 (2S,5S,6S)-3-aza-2-(p-bromobenzyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide 

Relevant articles and documents

OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. asthma and allergic diseases, gastrointestinal inflammatory diseases, eosinophilic diseases, chronic obstructive pulmonary disease, infection by pathogenic microbes, rheumatoid arthritis or atherosclerosis.

SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL] -2-AZABICYCLO [2.2.1] HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C

Disclosed are N-1-cyano-2-(phenyl)ethyl)-2-azabicyclo[2.2.1]heptane-3-carboxamides of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of respiratory diseases.