501015-24-3

Basic information

• Product Name: Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid
• Synonyms: (R)-N-BOC-3-NITRO-BETA-PHENYLALANINE;Boc-D-b-Phe(3-NO2)-OH;(R)-3-((tert-Butoxycarbonyl)aMino)-3-(3-nitrophenyl)propanoic acid;(Tert-Butoxy)Carbonyl (R)-3-Amino-3-(3-nitro-phenyl)propionic acid
• CAS NO: 501015-24-3
• Molecular Formula: C14H18N2O6
• Molecular Weight: 310.3
• Mol File: 501015-24-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 483.9°C at 760 mmHg
• Flash Point: 246.5°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 3.54E-10mmHg at 25°C
• Refractive Index: 1.552
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid(501015-24-3)
• EPA Substance Registry System: Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid(501015-24-3)

Safety Data

• Hazardous Substances Data: 501015-24-3(Hazardous Substances Data)

Usage

General Description

Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid is a chemical compound with the Boc (tert-butoxycarbonyl) protecting group attached to the amino group of the propanoic acid. Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid is a derivative of the natural amino acid proline, with a substituted nitrophenyl group attached to the alpha carbon. It is commonly used in organic synthesis and peptide chemistry as a building block for the creation of peptides and peptide mimetics. The Boc protecting group is often used to temporarily mask the reactivity of the amino group, allowing for selective functionalization at other sites within a molecule. The presence of the nitrophenyl group also imparts unique chemical reactivity and potential for biological activity, making Boc-(R)-3-amino-3-(3-nitro-phenyl)-propanoic acid a valuable tool in chemical and pharmaceutical research.

InChI:InChI=1/C14H18N2O6/c1-14(2,3)22-13(19)15-11(8-12(17)18)9-5-4-6-10(7-9)16(20)21/h4-7,11H,8H2,1-3H3,(H,15,19)(H,17,18)

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 5678-47-7 3-amino-3-(3-nitro-phenyl)-propionic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

CYTOSTATIC CONJUGATES WITH INTEGRIN LIGANDS

The present invention relates to novel pharmaceutical compounds comprising of an αvβ3 integrin antagonist, a linking unit comprising of L-Val – L-Pro – L-Asp cleavable by elastase, a polyethyleneglycol (PEG) spacer and a cytotoxic element, to processes for preparation thereof, to the use thereof for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.