501097-30-9Relevant articles and documents
Modelling, synthesis and biological evaluation of an ethidium-arginine conjugate linked to a ribonuclease mimic directed against TAR RNA of HIV-1
Patino, Nadia,Di Giorgio, Christophe,Dan-Covalciuc, Cristina,Peytou, Valérie,Terreux, Rapha?l,Cabrol-Bass, Daniel,Bailly, Christian,Condom, Roger
, p. 573 - 584 (2007/10/03)
Using molecular modelling studies, an active anti-HIV ethidium-arginine conjugate targeted against the viral TAR RNA sequence has been linked to an artificial ribonuclease, with the aim to obtain an irreversible inhibitor. The ribonuclease moiety consists of an N-[N-(3-aminopropyl)-3-aminopropyl] glycine and has been constructed via two successive N-alkylations following the Fukuyama procedure.