501126-37-0Relevant articles and documents
NOVEL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE 6 AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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Page/Page column 462; 464; 465, (2022/01/24)
The present invention relates to a new compound having an inhibitory activity of histone deacetylase 6 (HDAC6), stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in the preparation of a drug, a pharmaceutical composition comprising them, a prophylactic or therapeutic method corresponding, and a method of preparing a new derivative 1,3,4-oxadiazole triazol, a novel compound having selective HDAC6 inhibitory activity being represented by the following chemical formula I.
Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
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Page/Page column 26, (2008/06/13)
Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.