501684-29-3Relevant articles and documents
Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: Analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents
Wissner, Allan,Brawner Floyd,Rabindran, Sridhar K.,Nilakantan, Ramaswamy,Greenberger, Lee M.,Shen, Ru,Wang, Yu-Fen,Tsou, Hwei-Ru
, p. 2893 - 2897 (2007/10/03)
The syntheses and biological evaluations of 4-anilinoquinoline-3-carbonitrile analogues of the three clinical lead 4-anilinoquinazolines Iressa, Tarceva, and CI-1033 are described. The EGFR and HER-2 kinase inhibitory activities and the cell growth inhibition of the two series are compared with each other and with the clinical lead EKB-569. Similar activities are observed between these two series.