502-54-5

Basic information

• Product Name: MONOCAPRYLIN
• Synonyms: MONOCAPRYLIN;OCTANOIN;GLYCEROL ALPHA-MONOOCTANOATE;GLYCEROL MONOCAPRYLATE;1-MONOOCTANOYL-RAC-GLYCEROL;1-MONOCAPRYLOYL-RAC-GLYCEROL (C8:0);1-MONOCAPRYLIN;1-MONOOCTANOYL GLYCEROL
• CAS NO: 502-54-5
• Molecular Formula: C11H22O4
• Molecular Weight: 218.29
• Mol File: 502-54-5.mol
• Article Data: 14

Chemical Properties

• Melting Point: 39.5-40.5°
• Boiling Point: 340.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.044±0.06 g/cm3(Predicted)
• Storage Temp.: −20°C
• PKA: 13.16±0.20(Predicted)
• CAS DataBase Reference: MONOCAPRYLIN(CAS DataBase Reference)
• NIST Chemistry Reference: MONOCAPRYLIN(502-54-5)
• EPA Substance Registry System: MONOCAPRYLIN(502-54-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 502-54-5(Hazardous Substances Data)

Usage

Uses

1-Octanoyl-rac-glycerol is a monoacylglyecrol with antibacterial activity. 1-Octanoyl-rac-glycerol showed inhibition of oleic acid uptake by rat intestinal epithelial IEC-6 cells in vitro.

Brand name

Moctanin (Exelixis).

InChI:InChI=1/C11H22O4/c1-2-3-4-5-6-7-11(14)15-9-10(13)8-12/h10,12-13H,2-9H2,1H3

Upstream product

• 115228-29-0 (2,2-dimethyl-1,3-dioxolane-4-yl)methyl caprylate 
• 109587-92-0 1,3-benzylidene-2-octanoylglycerol 
• 4228-48-2 glycerin monocaprylate 
• 124-07-2 Octanoic acid 
• 56-81-5 glycerol 
• 111-64-8 n-octanoic acid chloride 
• 96-24-2 3-monochloro-1,2-propanediol 
• 538-23-8 tricaprilin 
• 623-66-5 octanoic acid anhydride 
• 818-44-0 vinyl octanoate 
• 111-11-5 methyl octanate 
• 556-52-5 oxiranyl-methanol 

Relevant articles and documents

METHOD FOR PREPARING MONOGLYCERIDES

The present application relates to a method for preparing monoglycerides, a method for recovering glycerin and catalysts after the process for preparing monoglycerides, and a process for preparing cyclic monoglycerides.(AA) Fatty acid glycerin catalyst(BB) Esterification(CC) Reuse(DD) Settling and separation(EE) Glycerin and most of catalyst(F1,F2) Glyceride layer(GG) Glycerin(HH) Washing and separation(II) Glycerin and traces of catalyst(JJ) Glyceride layer(KK) Molecular distillation(LL) Glycerin and unreacted fatty acid(MM) Di- and tri-glycerideCOPYRIGHT KIPO 2020

NOVEL METHOD OF USE AND COMPOSITIONS

The present invention is directed to a method for improving the occlusiveness of a topical pharmaceutical or cosmetic formulation in use in a patient in need thereof, comprising adding to the formulation at least 0.1- to about 10% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof. The present invention is also directed to a method for maintaining skin barrier efficiency of the stratum corneum of a patient in need thereof, comprising applying to the skin of said patient a pharmaceutical or cosmetic formulation containing at least 3 % w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.

1-O-Alkyl (di)glycerol ethers synthesis from methyl esters and triglycerides by two pathways: Catalytic reductive alkylation and transesterification/reduction

From available and bio-sourced methyl esters, monoglycerides or oleic sunflower refined oil, the corresponding 1-O-alkyl (di)glycerol ethers were obtained in both high yields and selectivity by two different pathways. With methyl esters, a reductive alkylation with (di)glycerol was realized under 50 bar hydrogen pressure in the presence of 1 mol% of Pd/C and an acid co-catalyst. A second two step procedure was evaluated from methyl esters or triolein and consisted of a first transesterification to the corresponding monoglyceride with a BaO/Al2O3 catalyst, then its reduction to the desired glycerol monoether with a recyclable heterogeneous catalytic system Pd/C and Amberlyst 35 under H2 pressure. In addition, a mechanism for the reaction was also proposed.