5022-26-4

Basic information

• Product Name: N-benzyl-2,2-diphenylacetamide
• Synonyms: benzeneacetamide, alpha-phenyl-N-(phenylmethyl)-
• CAS NO: 5022-26-4
• Molecular Formula: C₂₁H₁₉NO
• Molecular Weight: 301.3817
• Mol File: 5022-26-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 526.8°C at 760 mmHg
• Flash Point: 319.3°C
• Density: 1.119g/cm³
• Vapor Pressure: 3.47E-11mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: N-benzyl-2,2-diphenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2,2-diphenylacetamide(5022-26-4)
• EPA Substance Registry System: N-benzyl-2,2-diphenylacetamide(5022-26-4)

Safety Data

• Hazardous Substances Data: 5022-26-4(Hazardous Substances Data)

Usage

Description

N-benzyl-2,2-diphenylacetamide is a chemical compound with the molecular formula C21H19NO. It is a benzyl-substituted derivative of 2,2-diphenylacetamide, featuring a benzyl group attached to the nitrogen atom of the acetamide functional group.

Uses

Used in Pharmaceutical Synthesis:
N-benzyl-2,2-diphenylacetamide is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs.
Used in Organic Chemistry:
It serves as a building block in organic chemistry, facilitating the creation of various complex organic molecules.
Used in Antimicrobial Applications:
N-benzyl-2,2-diphenylacetamide is being investigated for its potential antimicrobial properties, which could lead to its use in the development of new antimicrobial agents.
Used in Antifungal Applications:
N-benzyl-2,2-diphenylacetamide is also being explored for its antifungal properties, indicating its potential use in treating fungal infections.
Used in Antiparasitic Applications:
Its antiparasitic properties are of interest in the development of new drugs to combat parasitic diseases.
Used in Anti-inflammatory Applications:
N-benzyl-2,2-diphenylacetamide exhibits significant anti-inflammatory effects, making it a candidate for use in medications aimed at reducing inflammation.
Used in Analgesic Applications:
Due to its analgesic effects, the compound has potential applications in pain management and the development of pain-relief medications.

Upstream product

• 17172-88-2 N-benzyl-2-bromo-2-phenylethanamide 
• 1871-76-7 diphenylacetic acid chloride 
• 100-46-9 benzylamine 
• 81838-76-8 N-Benzyl-N'-hydroxy-2,2-diphenyl-acetamidine 
• 117-34-0 2,2-diphenylacetic acid 
• 124116-92-3 1,2-dibenzyl-4,4-diphenyl-[1,2]diazetidin-3-one 
• 7664-41-7 ammonia 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 525-06-4 diphenyl ketene 
• 4467-90-7 N-hydroxy-2,2-diphenylacetimidoyl chloride 
• 19078-72-9 bromo(phenyl)acetyl chloride 
• 4545-20-4 benzophenone tosylhydrazone 
• 13939-06-5 molybdenum hexacarbonyl 
• 4695-13-0 2,2-diphenylacetamide 

Downstream Products

• 26907-06-2 2-benzhydrylidene-3-benzyl-5-isopropyl-[1,3]oxazinane-4,6-dione 

Relevant articles and documents

A simple route to side-chain fluorinated β-lactams from ring-fluorinated aziridines

β-Lactams bearing a Ph2CF substituent at the C(4)-atom were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure.

9-Silafluorenyl Dichlorides as Chemically Ligating Coupling Agents and Their Application in Peptide Synthesis

A fundamentally simple, mild, and practical procedure for peptide bond formation is reported that employs a stoichiometric amount of easy-to-access 9-silafluorenyl dichlorides as the coupling agent. Without initial preactivation or elaboration of the carboxylic acid or amine termini of the amino acids, the developed reagent is proposed to act through an unprecedented chemical ligation mechanism, bringing the two coupling partners together before being subsequently eliminated. The desired amides or peptide bonds are thus furnished in good yields and with low to no epimerization.

A One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using pph3/n-chlorobenzotriazole system

Triphenylphosphine (PPh3)/N-chlorobenzotriazole (NCBT), and amine (primary and secondary aliphatic amines and also substituted anilines) in CH2Cl2 efficiently converted carboxylic acids, α-amino acids, and sulfonic acids to the corresponding amides and sulfonamides at room temperature. Good to excellent yields, inexpensive, and fast reaction conditions are the important features of this procedure.