502649-29-8

Basic information

• Product Name: 1-Boc-3-Benzylpiperazine
• Synonyms: 3-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-1-BOC-3-BENZYL-PIPERAZINE;1-N-Boc-3-benzylpiperazine;1-Boc-3-benzyl-piperazine;N-1-BOC-3-BENZYL PIPERIZINE;1-N-Boc-3-benzylpiperizine;N-1-Boc-3-Benzyl;N-Boc-3-benzylpiperazine
• CAS NO: 502649-29-8
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37
• Product Categories: Piperazine series;Piperaizine
• Mol File: 502649-29-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 379.8oC at 760 mmHg
• Flash Point: 183.5oC
• Appearance: /
• Density: 1.066g/cm3
• Vapor Pressure: 5.7E-06mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.45±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-Benzylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-Benzylpiperazine(502649-29-8)
• EPA Substance Registry System: 1-Boc-3-Benzylpiperazine(502649-29-8)

Safety Data

• Hazardous Substances Data: 502649-29-8(Hazardous Substances Data)

Usage

Uses

1-Boc-3-benzylpiperazine is a useful reactant/reagent for organic reactions and synthesis.

InChI:InChI=1/C16H24N2O2/c1-16(2,3)20-15(19)18-10-9-17-14(12-18)11-13-7-5-4-6-8-13/h4-8,14,17H,9-12H2,1-3H3

Upstream product

• 847554-73-8 tert-butyl 3-oxo-1-phenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 216228-85-2 2-formylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 181955-79-3 N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid 
• 63-91-2 L-phenylalanine 

Downstream Products

• 1007352-17-1 3-benzyl-4-[1-(tert-butyl-dimethyl-silanyl)-1H-indol-5-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 481038-64-6 benzyl-2-benzylpiperazine-1-carboxylate 
• 481038-65-7 2-(3-benzyl-piperazin-1-yl)-N-(3-methanesulfonylamino-phenyl)-acetamide 
• 481038-66-8 4-[(3-amino-phenylcarbamoyl)-methyl]-2-benzyl-piperazine-1-carboxylic acid benzyl ester 
• 481038-62-4 2-benzyl-4-[(3-nitro-phenylcarbamoyl)-methyl]-piperazine-1-carboxylic acid benzyl ester 
• 481038-67-9 2-benzyl-4-[(3-methanesulfonylamino-phenylcarbamoyl)-methyl]-piperazine-1-carboxylic acid benzyl ester 
• 947278-72-0 C₃₅H₃₉N₃O₃ 
• 947278-71-9 C₂₉H₃₅N₃O₃ 
• 84477-71-4 2-(S)-Benzyl-piperazine 

Relevant articles and documents

An orthogonal protection strategy for the synthesis of 2-substituted piperazines

Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones are readily prepared from the bis-carbamate protected piperazine-2-carboxylic acids and serve as orthogonally protected piperazines from which a variety of 2-substituted piperazines can be prepared. Sodium benzylate and sodium phenoxides react at the C-5 carbon of the oxazolidinone to yield 2-(benzyloxymethyl)piperazines and 2-(phenoxymethyl)piperazines, respectively. The tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones also provide convenient scaffolds from which 2-benzyl- and 2-phenethylpiperazines are prepared.