502686-01-3

Basic information

• Product Name: 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine
• Synonyms: 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine
• CAS NO: 502686-01-3
• Molecular Formula: C₉H₇F₃N₄
• Molecular Weight: 228.17
• Mol File: 502686-01-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 400.9 °C at 760 mmHg
• Flash Point: 196.3 °C
• Appearance: /
• Density: 1.469
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine(502686-01-3)
• EPA Substance Registry System: 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine(502686-01-3)

Safety Data

• Hazardous Substances Data: 502686-01-3(Hazardous Substances Data)

Usage

General Description

5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine is a chemical compound that belongs to the triazol-3-amine family. It is a derivative of the triazole ring system and contains a trifluoromethylphenyl group. 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine has potential applications in the field of medicinal chemistry, particularly as a scaffold for the development of new drugs. The trifluoromethyl group is known to impart unique properties to molecules, making them valuable for drug design. Additionally, the triazole ring system is known for its biological activity, and compounds containing this moiety have been investigated for their antimicrobial, antifungal, antiviral, and anticancer properties. Therefore, 5-(3-(Trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-amine may hold promise for the development of new pharmaceuticals with therapeutic potential.

InChI:InChI=1/C9H7F3N4/c10-9(11,12)6-3-1-2-5(4-6)7-14-8(13)16-15-7/h1-4H,(H3,13,14,15,16)

Upstream product

• 2557-13-3 3-trifluoromethylbenzoic acid methyl ester 
• 2582-30-1 aminoguanidine bicarbonate 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 22227-25-4 3-(trifluoromethyl)benzene-1-carbohydrazide 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Downstream Products

• 1354721-88-2 5-chloro-2-nitro-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)-benzamide 
• 1354721-89-3 2-nitro-5-(piperidin-1-yl)-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)benzamide 
• 1354721-90-6 2-amino-5-(piperidin-1-yl)-N-(5-(3-(trifluoromethyl)phenyl)-2H-1,2,4-triazol-3-yl)benzamide 
• 1456613-74-3 5-thioxo-2-(3-(trifluoromethyl)phenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one 

Relevant articles and documents

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5] triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities

Thirty-three 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues were designed and synthesized which contained different substituents at meta- and/or para-positions of 2-phenyl or 2-benzyl ring attached to the fused ring structure. Th